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<p>Real-time, non-invasive imaging techniques are essential for advancing biomedical diagnostics and material analysis, yet existing terahertz (THz) systems often suffer from limited speed, bulky designs, and poor adaptability to in situ environments. Addressing these challenges, we present a fully fibre-coupled THz attenuated total internal reflection single-pixel imaging system, offering a compact, flexible, and robust platform for non-destructive spectroscopy and in vivo imaging. This all-fibre architecture enables seamless integration for in situ biomedical applications, including measurements directly on patients. Central to our design is a THz spatial light modulator based on an unpassivated silicon wafer, facilitating high-speed modulation and enabling video-rate imaging with a spatial resolution down to 360 <i>μ</i>m. Despite being in the reflection geometry and using fibre-coupled light, our system achieves an imaging throughput exceeding 30,000 pixels per second for 64-by-64 images - over five-fold higher than the state of the art - representing a substantial improvement in real-time THz imaging capabilities.</p>

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All-fibre-coupled terahertz single-pixel imaging for biomedical applications

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月12日

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  • Sen Mou,
  • Rayko I. Stantchev,
  • Sonal Saxena,
  • Huiliang Ou,
  • Shreeya Rane,
  • Sophie L. Pain,
  • John D. Murphy,
  • Euan Hendry,
  • James Lloyd-Hughes,
  • Emma Pickwell-MacPherson

摘要

Real-time, non-invasive imaging techniques are essential for advancing biomedical diagnostics and material analysis, yet existing terahertz (THz) systems often suffer from limited speed, bulky designs, and poor adaptability to in situ environments. Addressing these challenges, we present a fully fibre-coupled THz attenuated total internal reflection single-pixel imaging system, offering a compact, flexible, and robust platform for non-destructive spectroscopy and in vivo imaging. This all-fibre architecture enables seamless integration for in situ biomedical applications, including measurements directly on patients. Central to our design is a THz spatial light modulator based on an unpassivated silicon wafer, facilitating high-speed modulation and enabling video-rate imaging with a spatial resolution down to 360 μm. Despite being in the reflection geometry and using fibre-coupled light, our system achieves an imaging throughput exceeding 30,000 pixels per second for 64-by-64 images - over five-fold higher than the state of the art - representing a substantial improvement in real-time THz imaging capabilities.