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<p>The O1 serogroup of <i>Vibrio cholerae</i> has caused all cholera pandemics and for over a century <i>V. cholerae</i> O1 outbreak strains have been characterized by their serotype. The two <i>V. cholerae</i> serotypes differ by the presence (Ogawa) or absence (Inaba) of methylation of the terminal sugar on the lipopolysaccharide O1-antigen. Serotype switching often occurs during epidemics and has historically been attributed to the pathogen adapting to immune pressures. Here we address the impact of serotype on <i>V. cholerae</i> pathogenicity using otherwise isogenic Ogawa and Inaba versions of several clinical <i>V. cholerae</i> O1 isolates. Our findings indicate that O1 antigen methylation in Ogawa strains promotes <i>V. cholerae</i> colonization, infectivity and resistance to antimicrobial peptides. We propose that methylation of the O1 antigen elevates colonization by shielding the bacterium from cationic antimicrobial peptides at the pH of the small intestine. These observations provide insights into the biological significance of the <i>V. cholerae</i> O1 serotypes.</p>

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Vibrio cholerae serotype impacts pathogenicity

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月19日

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  • Franz G. Zingl,
  • Deborah R. Leitner,
  • Bolutife Fakoya,
  • Alexander A. Morano,
  • Matthew K. Waldor

摘要

The O1 serogroup of Vibrio cholerae has caused all cholera pandemics and for over a century V. cholerae O1 outbreak strains have been characterized by their serotype. The two V. cholerae serotypes differ by the presence (Ogawa) or absence (Inaba) of methylation of the terminal sugar on the lipopolysaccharide O1-antigen. Serotype switching often occurs during epidemics and has historically been attributed to the pathogen adapting to immune pressures. Here we address the impact of serotype on V. cholerae pathogenicity using otherwise isogenic Ogawa and Inaba versions of several clinical V. cholerae O1 isolates. Our findings indicate that O1 antigen methylation in Ogawa strains promotes V. cholerae colonization, infectivity and resistance to antimicrobial peptides. We propose that methylation of the O1 antigen elevates colonization by shielding the bacterium from cationic antimicrobial peptides at the pH of the small intestine. These observations provide insights into the biological significance of the V. cholerae O1 serotypes.