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<p>Organ functionalization is inherently complex and dynamic, involving multilayered tissue structures and continuous cellular remodeling. To address the clinical need for long-segment tracheal reconstruction, we propose a dynamic tissue engineering (DTE) strategy using a bio-adaptive physical hydrogel (BP-Gel) to emulate native tracheal development and enable dynamic regeneration of key tissue components. Here we show that chondrocytes cultured within BP-Gel form cartilage rings through an embryo-like chondrification process, during which the gel’s percolation network adapts to cell migration and aggregation. The resulting cartilage exhibits a native-like multilayered morphology that enhances mechanical stability and resists degradation. Before transplantation, BP-Gel loaded with anti-inflammatory cytokines (IL-Gel) is introduced into inter-ring spaces to suppress inflammation and promote vascularization and epithelial maturation. In a rabbit tracheal defect model, this strategy reconstructs a functional trachea mimicking native structure and physiology, offering a promising, clinically relevant route to tracheal reconstruction.</p>

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A bio-adaptive physical hydrogel enables dynamic tissue engineering for tracheal reconstruction

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月14日

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  • Hai Tang,
  • Hanchen Wang,
  • Weiyan Sun,
  • Yi Chen,
  • Ziyin Pan,
  • Qingfeng Bai,
  • Yaoben Wang,
  • Weikang Lin,
  • Yulong Hu,
  • Lei Wang,
  • Minglei Yang,
  • Guofang Zhao,
  • Lei Zhang,
  • Yunlang She,
  • Xuefei Hu,
  • Kewen Lei,
  • Jiandong Ding,
  • Lin Yu,
  • Chang Chen

摘要

Organ functionalization is inherently complex and dynamic, involving multilayered tissue structures and continuous cellular remodeling. To address the clinical need for long-segment tracheal reconstruction, we propose a dynamic tissue engineering (DTE) strategy using a bio-adaptive physical hydrogel (BP-Gel) to emulate native tracheal development and enable dynamic regeneration of key tissue components. Here we show that chondrocytes cultured within BP-Gel form cartilage rings through an embryo-like chondrification process, during which the gel’s percolation network adapts to cell migration and aggregation. The resulting cartilage exhibits a native-like multilayered morphology that enhances mechanical stability and resists degradation. Before transplantation, BP-Gel loaded with anti-inflammatory cytokines (IL-Gel) is introduced into inter-ring spaces to suppress inflammation and promote vascularization and epithelial maturation. In a rabbit tracheal defect model, this strategy reconstructs a functional trachea mimicking native structure and physiology, offering a promising, clinically relevant route to tracheal reconstruction.