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<p>Low-valent sulfur-containing compounds are abundant among natural and synthetic products but remain underutilized as starting materials in desulfurative transformations. Herein, we present thiols, disulfides, thioethers, and thioacetals as precursors in a direct desulfurative electrochemical process for the formation of alkylboronic esters, including late-stage functionalization of pharmaceutically relevant scaffolds and natural products. The electrochemical protocol is simple, user-friendly and scalable, successfully producing gram quantities of borylated product.</p>

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Electrochemical desulfurative borylation of thiols, disulfides, thioethers and thioacetals

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月15日

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  • Julius Kuzmin,
  • Cristiana Margarita,
  • Johannes Winter,
  • Helena Lundberg

摘要

Low-valent sulfur-containing compounds are abundant among natural and synthetic products but remain underutilized as starting materials in desulfurative transformations. Herein, we present thiols, disulfides, thioethers, and thioacetals as precursors in a direct desulfurative electrochemical process for the formation of alkylboronic esters, including late-stage functionalization of pharmaceutically relevant scaffolds and natural products. The electrochemical protocol is simple, user-friendly and scalable, successfully producing gram quantities of borylated product.