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<p>Piezoelectric catalysis enhances therapeutic outcomes in nanocatalysis but is limited by intrinsic catalysis mechanism. This study employs sub-nanometer Hf<sub>0.5</sub>Zr<sub>0.5</sub>O<sub>2</sub> (HZO) nanowires as a piezoelectric catalyst to address these challenges. Oxygen K-edge X-ray absorption spectroscopy and spherical aberration-corrected transmission electron microscopy reveal the orthorhombic phase (<i>Pca21</i>) in HZO nanowires. This structure imparts polymer-like flexibility to Hf<sub>0.5</sub>Zr<sub>0.5</sub>O<sub>2</sub>, improving its sensitivity to mechanical stress. Molecular dynamics and first-principles calculations demonstrate that ultrasonic stimulation increases the mobility of oxygen bridges, facilitating efficient ferroelectric polarization reversal. This mechanism breaks the “scaling relationship” between the low activation energy for reactant adsorption and the high activation energy for product desorption, enabling significant hydroxyl radical generation. Additionally, hydrogen produced during catalysis promotes pyroptosis, enhancing CD8<sup>+</sup> T cell infiltration and reversing tumor immunosuppression. This research underscores the potential of sub-nanoscale ferroelectric materials in anti-tumor applications.</p>

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Constructing flexible sub-nanometer ferroelectric catalyst to overcome heterocatalytic kinetic barriers for enhanced catalytic and immuno-therapy

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月16日

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  • Rui Zhang,
  • Yuanfei Yao,
  • Lu Yang,
  • Xudong Zhao,
  • Boshi Tian,
  • Dan Yang,
  • Piaoping Yang

摘要

Piezoelectric catalysis enhances therapeutic outcomes in nanocatalysis but is limited by intrinsic catalysis mechanism. This study employs sub-nanometer Hf0.5Zr0.5O2 (HZO) nanowires as a piezoelectric catalyst to address these challenges. Oxygen K-edge X-ray absorption spectroscopy and spherical aberration-corrected transmission electron microscopy reveal the orthorhombic phase (Pca21) in HZO nanowires. This structure imparts polymer-like flexibility to Hf0.5Zr0.5O2, improving its sensitivity to mechanical stress. Molecular dynamics and first-principles calculations demonstrate that ultrasonic stimulation increases the mobility of oxygen bridges, facilitating efficient ferroelectric polarization reversal. This mechanism breaks the “scaling relationship” between the low activation energy for reactant adsorption and the high activation energy for product desorption, enabling significant hydroxyl radical generation. Additionally, hydrogen produced during catalysis promotes pyroptosis, enhancing CD8+ T cell infiltration and reversing tumor immunosuppression. This research underscores the potential of sub-nanoscale ferroelectric materials in anti-tumor applications.