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<p>Breast cancer (BC) is a major health concern affecting millions of women worldwide. This study (NCT04217109) explores canine odorology as a method for identifying BC using patient sweat samples. To collect the sweat samples, the night before biopsies, a compress is applied to the affected breast and the sample is subsequently presented to two trained dogs during the training or testing sessions. A positive cancer detection is indicated if a dog halts in front of the compress. A total of 181 patients participate, 107 with breast cancer (82 invasive and 25 in situ) and 74 with benign lesions. Sensitivity (Se) is 68% and specificity (Sp) 27% for a single randomly selected dog. When at least one dog marks a sample, Se rises to 80.4% but Sp drops to 21.6%. If both dogs mark it, Se is 48.6% and Sp 45.9%. Results show limited ability to distinguish benign from malignant lesions. Dogs perform best with mixed samples but struggle when all are negative, with variable responses between dogs. Identifying BC-specific volatile compounds may improve accuracy.</p>

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A prospective trial for breast cancer diagnosis by canine odorology

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月27日

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  • Anne Tardivon,
  • Benoit Mesurolle,
  • Sylvain Dureau,
  • Edouard Poncelet,
  • François Dravet,
  • Adriana Langer,
  • Marie-Rose El Bejjani,
  • Séverine Alran,
  • Elise Deluche,
  • Alexia Savignoni,
  • Amir Kadi,
  • Pierre Bauër,
  • Caroline Gilbert,
  • Michelle Leemans,
  • Isabelle Fromantin

摘要

Breast cancer (BC) is a major health concern affecting millions of women worldwide. This study (NCT04217109) explores canine odorology as a method for identifying BC using patient sweat samples. To collect the sweat samples, the night before biopsies, a compress is applied to the affected breast and the sample is subsequently presented to two trained dogs during the training or testing sessions. A positive cancer detection is indicated if a dog halts in front of the compress. A total of 181 patients participate, 107 with breast cancer (82 invasive and 25 in situ) and 74 with benign lesions. Sensitivity (Se) is 68% and specificity (Sp) 27% for a single randomly selected dog. When at least one dog marks a sample, Se rises to 80.4% but Sp drops to 21.6%. If both dogs mark it, Se is 48.6% and Sp 45.9%. Results show limited ability to distinguish benign from malignant lesions. Dogs perform best with mixed samples but struggle when all are negative, with variable responses between dogs. Identifying BC-specific volatile compounds may improve accuracy.