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<p>Tooth enamel is characterised by an intricate hierarchical organization of apatite nanocrystals that bestows high stiffness, hardness, and fracture toughness. However, enamel does not possess the ability to regenerate, and achieving the artificial restoration of its microstructure and mechanical properties in clinical settings has proven challenging. To tackle this issue, we engineer a tuneable and resilient supramolecular matrix based on elastin-like recombinamers (ELRs) that imitates the structure and function of the enamel-developing matrix. When applied as a coating on the surface of teeth exhibiting different levels of erosion, the matrix is stable and can trigger epitaxial growth of apatite nanocrystals, recreating the microarchitecture of the different anatomical regions of enamel and restoring the mechanical properties. The study demonstrates the translational potential of our mineralising technology for treating loss of enamel in clinical settings such as the treatment of enamel erosion and dental hypersensitivity.</p>

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Biomimetic supramolecular protein matrix restores structure and properties of human dental enamel

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月4日

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  • Abshar Hasan,
  • Andrey Chuvilin,
  • Alexander Van Teijlingen,
  • Helena Rouco,
  • Christopher Parmenter,
  • Federico Venturi,
  • Michael Fay,
  • Gabriele Greco,
  • Nicola M. Pugno,
  • Jan Ruben,
  • Charlotte J. C. Edwards-Gayle,
  • Benjamin Myers,
  • Ingrid Dreveny,
  • Nathan Cowieson,
  • Adam Winter,
  • Sara Gamea,
  • X. Frank Walboomers,
  • Tanvir Hussain,
  • José Carlos Rodríguez-Cabello,
  • Frankie Rawson,
  • Tell Tuttle,
  • Sherif Elsharkawy,
  • Avijit Banerjee,
  • Stefan Habelitz,
  • Alvaro Mata

摘要

Tooth enamel is characterised by an intricate hierarchical organization of apatite nanocrystals that bestows high stiffness, hardness, and fracture toughness. However, enamel does not possess the ability to regenerate, and achieving the artificial restoration of its microstructure and mechanical properties in clinical settings has proven challenging. To tackle this issue, we engineer a tuneable and resilient supramolecular matrix based on elastin-like recombinamers (ELRs) that imitates the structure and function of the enamel-developing matrix. When applied as a coating on the surface of teeth exhibiting different levels of erosion, the matrix is stable and can trigger epitaxial growth of apatite nanocrystals, recreating the microarchitecture of the different anatomical regions of enamel and restoring the mechanical properties. The study demonstrates the translational potential of our mineralising technology for treating loss of enamel in clinical settings such as the treatment of enamel erosion and dental hypersensitivity.