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<p>Pathogenic variants in ATP-dependent chromatin remodeling proteins are a recurrent cause of neurodevelopmental disorders (NDDs). The NURF complex consists of BPTF and either the SMARCA5 or SMARCA1 ISWI-chromatin remodeling enzyme. Pathogenic variants in <i>BPTF</i> and <i>SMARCA5</i> have been previously implicated in NDDs. Here, we describe 35 individuals from 26 families with de novo or maternally inherited variants in the X-linked <i>SMARCA1</i> gene. This SMARCA1-related NDD is associated with a spectrum of involvement, including mild to severe ID/DD, delayed or regressive speech development, ASD features, facial dysmorphisms, and other variable features. Individuals carrying <i>SMARCA1</i> truncating variants exhibit a mildly unique genome-wide DNA methylation profile and a high penetrance of macrocephaly. Genetic dissection of the NURF complex using <i>Smarca1</i>, <i>Smarca5</i>, and <i>Bptf</i> single and double mouse knockouts reveals the importance of NURF composition and dosage for proper forebrain development. We propose that genetic alterations affecting different NURF components, including <i>SMARCA1</i>, result in a NDD with a broad clinical spectrum.</p>

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Pathogenic variants in SMARCA1 cause an X-linked neurodevelopmental disorder modulated by NURF complex composition

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月10日

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  • Ghayda M. Mirzaa,
  • Keqin Yan,
  • Raissa Relator,
  • Mathieu Levesque,
  • Pranisha Jayasinghe,
  • Sara Timpano,
  • Binnaz Yalcin,
  • Stephan Collins,
  • Alban Ziegler,
  • Emily Pao,
  • Nora Oyama,
  • Elise Brischoux-Boucher,
  • Juliette Piard,
  • Kristin G. Monaghan,
  • Maria. J. Guillen Sacoto,
  • William B. Dobyns,
  • Kristen L. Park,
  • Daniel Martin Fernández-Mayoralas,
  • Alberto Fernández-Jaén,
  • Parul Jayakar,
  • María Palomares-Bralo,
  • Fernando Santos-Simarro,
  • Alfredo Brusco,
  • Vincenzo Antona,
  • Elisa Giorgio,
  • Malin Kvarnung,
  • Bertrand Isidor,
  • Solène Conrad,
  • Benjamin Cogné,
  • Wallid Deb,
  • Kyra E. Stuurman,
  • Katalin Štěrbová,
  • Noor Smal,
  • Sarah Weckhuysen,
  • Renske Oegema,
  • A. Micheil Innes,
  • Daniel. C. Koboldt,
  • Tawfeg Ben-Omran,
  • Rebecca C. Yeh,
  • Michael C. Kruer,
  • Somayeh Bakhtiari,
  • Antigone Papavasiliou,
  • Sébastien Moutton,
  • Sophie Nambot,
  • Sirisak Chanprasert,
  • Sarah A. Paolucci,
  • Kait Miller,
  • Barbara Burton,
  • Katherine Kim,
  • Emily O’Heir,
  • Zandre Bruwer,
  • Kirsten. A. Donald,
  • Tjitske Kleefstra,
  • Amy Goldstein,
  • Brad Angle,
  • Kelly Bontempo,
  • Peter Miny,
  • Pascal Joset,
  • Florence Demurger,
  • Emma Hobson,
  • Lewis Pang,
  • Lori Carpenter,
  • Dong Li,
  • Dominique Bonneau,
  • Bekim Sadikovic,
  • David J. Picketts

摘要

Pathogenic variants in ATP-dependent chromatin remodeling proteins are a recurrent cause of neurodevelopmental disorders (NDDs). The NURF complex consists of BPTF and either the SMARCA5 or SMARCA1 ISWI-chromatin remodeling enzyme. Pathogenic variants in BPTF and SMARCA5 have been previously implicated in NDDs. Here, we describe 35 individuals from 26 families with de novo or maternally inherited variants in the X-linked SMARCA1 gene. This SMARCA1-related NDD is associated with a spectrum of involvement, including mild to severe ID/DD, delayed or regressive speech development, ASD features, facial dysmorphisms, and other variable features. Individuals carrying SMARCA1 truncating variants exhibit a mildly unique genome-wide DNA methylation profile and a high penetrance of macrocephaly. Genetic dissection of the NURF complex using Smarca1, Smarca5, and Bptf single and double mouse knockouts reveals the importance of NURF composition and dosage for proper forebrain development. We propose that genetic alterations affecting different NURF components, including SMARCA1, result in a NDD with a broad clinical spectrum.