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<p>Skeletal muscles, which constitute 40–50% of body mass, regulate whole-body energy expenditure and glucose and lipid metabolism. Peroxisomes are dynamic organelles that play a crucial role in lipid metabolism and clearance of reactive oxygen species, however their role in skeletal muscle remains poorly understood. To clarify this issue, we generated a muscle-specific transgenic mouse line with peroxisome import deficiency through the deletion of peroxisomal biogenesis factor 5 (<i>Pex5</i>). Here, we show that <i>Pex5</i> inhibition results in impaired lipid metabolism, reduced muscle force and exercise performance. Moreover, mitochondrial structure, content, and function are also altered, accelerating the onset of age-related structural defects, neuromuscular junction degeneration, and muscle atrophy. Consistent with these observations, we observe a decline in peroxisomal content in the muscles of control mice undergoing natural aging. Altogether, our findings show the importance of preserving peroxisomal function and their interplay with mitochondria to maintain muscle health during aging.</p>

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Alterations in peroxisome-mitochondria interplay in skeletal muscle accelerate muscle dysfunction

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月10日

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  • Marco Scalabrin,
  • Eloisa Turco,
  • Ilaria Davigo,
  • Riccardo Filadi,
  • Leonardo Nogara,
  • Gaia Gherardi,
  • Lucia Barazzuol,
  • Andrea Armani,
  • Giulia Trani,
  • Samuele Negro,
  • Anais Franco-Romero,
  • Yorrick Jaspers,
  • Elisa Baschiera,
  • Rossella De Cegli,
  • Eugenio Del Prete,
  • Tito Cali,
  • Bert Blaauw,
  • Leonardo Salviati,
  • Michela Rigoni,
  • Cristina Mammucari,
  • Sylvie Caspar-Bauguil,
  • Cedric Moro,
  • Paola Pizzo,
  • Marco Sandri,
  • Stephan Kemp,
  • Vanina Romanello

摘要

Skeletal muscles, which constitute 40–50% of body mass, regulate whole-body energy expenditure and glucose and lipid metabolism. Peroxisomes are dynamic organelles that play a crucial role in lipid metabolism and clearance of reactive oxygen species, however their role in skeletal muscle remains poorly understood. To clarify this issue, we generated a muscle-specific transgenic mouse line with peroxisome import deficiency through the deletion of peroxisomal biogenesis factor 5 (Pex5). Here, we show that Pex5 inhibition results in impaired lipid metabolism, reduced muscle force and exercise performance. Moreover, mitochondrial structure, content, and function are also altered, accelerating the onset of age-related structural defects, neuromuscular junction degeneration, and muscle atrophy. Consistent with these observations, we observe a decline in peroxisomal content in the muscles of control mice undergoing natural aging. Altogether, our findings show the importance of preserving peroxisomal function and their interplay with mitochondria to maintain muscle health during aging.