<p>Understanding the brain requires modeling large-scale neural dynamics, where coarse-grained modeling of macroscopic brain behaviors is a powerful paradigm for linking brain structure to function with empirical data. However, the model inversion process remains computationally intensive and time-consuming, limiting research efficiency and medical deployment. In this work, we present a pipeline bridging coarse-grained brain modeling and advanced computing architectures. We introduce a dynamics-aware quantization framework that enables accurate low-precision simulation with maintained dynamical characteristics, thereby addressing the precision challenges inherent in the brain-inspired computing architecture. Furthermore, to exploit hardware capabilities, we develop hierarchical parallelism mapping strategies tailored for brain-inspired computing chips and GPUs. Experimental results demonstrate that the deployed low-precision models maintain high functional fidelity while achieving tens to hundreds-fold acceleration over commonly used CPUs. This work provides essential computational infrastructures for modeling macroscopic brain dynamics and extends the application of brain-inspired computing to scientific computing in neuroscience and medicine.</p>