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<p>Photoreceptor degeneration in <i>Retinitis pigmentosa</i> (RP) is a leading cause of inherited blindness, for which few effective treatments are available. Graphene’s exceptional electrical, optical, and mechanical properties, along with its biocompatibility, make it a promising material for retinal stimulation. Building on prior success with conjugated polymers in rodent RP models, we developed injectable retinal nanoimplants that blend a donor-acceptor polymeric architecture with graphene oxide flakes. Here we show that graphene significantly improved the photovoltaic efficiency and enhanced light-evoked responses in blind retinal explants. In RP-affected Royal College of Surgeons rats, a single subretinal injection of these nanoimplants restored light-driven behaviors and visual brain activity at lower luminances than polymer-only particles without any proinflammatory effects. Moreover, this technology restored retinal activity in a pig model of chemically induced degeneration, demonstrating the valuable translational potential of the injectable nanoplatform in the treatment of retinal degenerative diseases.</p>

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Graphene oxide increases the phototransduction efficiency of copolymeric nanoimplants and rescues visual functions in rat and pig models of Retinitis pigmentosa

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月30日

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  • F. Galluzzi,
  • S. Francia,
  • S. Cupini,
  • T. Gianiorio,
  • G. Mantero,
  • M. L. DiFrancesco,
  • T. Ravasenga,
  • Jasnoor,
  • M. Attanasio,
  • J. F. Maya-Vetencourt,
  • G. Pertile,
  • D. Ventrella,
  • A. Elmi,
  • M. L. Bacci,
  • S. Di Marco,
  • F. Benfenati,
  • E. Colombo

摘要

Photoreceptor degeneration in Retinitis pigmentosa (RP) is a leading cause of inherited blindness, for which few effective treatments are available. Graphene’s exceptional electrical, optical, and mechanical properties, along with its biocompatibility, make it a promising material for retinal stimulation. Building on prior success with conjugated polymers in rodent RP models, we developed injectable retinal nanoimplants that blend a donor-acceptor polymeric architecture with graphene oxide flakes. Here we show that graphene significantly improved the photovoltaic efficiency and enhanced light-evoked responses in blind retinal explants. In RP-affected Royal College of Surgeons rats, a single subretinal injection of these nanoimplants restored light-driven behaviors and visual brain activity at lower luminances than polymer-only particles without any proinflammatory effects. Moreover, this technology restored retinal activity in a pig model of chemically induced degeneration, demonstrating the valuable translational potential of the injectable nanoplatform in the treatment of retinal degenerative diseases.