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<p>L-3,4-dihydroxyphenylalanine (L-DOPA), a naturally occurring tyrosine derivative, is prevalent in environments that include mosquito habitats, potentially serving as part of their diet. Given its role as a precursor for melanin synthesis we investigate the effect of dietary L-DOPA on mosquito physiology and immunity to <i>Plasmodium falciparum</i> and <i>Cryptococcus neoformans</i> infection. Dietary L-DOPA is incorporated into mosquito melanin via a non-canonical pathway and has a profound transcriptional effect associated with enhanced immunity, increased pigmentation, and reduced lifespan. Increased melanization results in an enhanced capacity to absorb electromagnetic radiation that affects mosquito temperatures. Bacteria in the mosquito microbiome act as sources of dopamine, a substrate for melanization. Our results illustrate how an environmentally abundant amino acid analogue can affect mosquito physiology and suggest its potential usefulness as an environmentally friendly vector control agent to reduce malaria transmission, warranting further research and field studies.</p>

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Dietary L-3,4-dihydroxyphenylalanine (L-DOPA) augments cuticular melanization in Anopheles mosquitos reducing their lifespan and malaria burden

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月27日

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  • Emma Camacho,
  • Yuemei Dong,
  • Christine Chrissian,
  • Radames J. B. Cordero,
  • Raúl G. Saraiva,
  • Yesseinia Anglero-Rodriguez,
  • Daniel F. Q. Smith,
  • Ella Jacobs,
  • Isabella Hartshorn,
  • J. Alberto Patiño-Medina,
  • Michael DePasquale,
  • Amanda Dziedzic,
  • Anne Jedlicka,
  • Barbara Smith,
  • Godfree Mlambo,
  • Abhai Tripathi,
  • Nichole A. Broderick,
  • Ruth E. Stark,
  • George Dimopoulos,
  • Arturo Casadevall

摘要

L-3,4-dihydroxyphenylalanine (L-DOPA), a naturally occurring tyrosine derivative, is prevalent in environments that include mosquito habitats, potentially serving as part of their diet. Given its role as a precursor for melanin synthesis we investigate the effect of dietary L-DOPA on mosquito physiology and immunity to Plasmodium falciparum and Cryptococcus neoformans infection. Dietary L-DOPA is incorporated into mosquito melanin via a non-canonical pathway and has a profound transcriptional effect associated with enhanced immunity, increased pigmentation, and reduced lifespan. Increased melanization results in an enhanced capacity to absorb electromagnetic radiation that affects mosquito temperatures. Bacteria in the mosquito microbiome act as sources of dopamine, a substrate for melanization. Our results illustrate how an environmentally abundant amino acid analogue can affect mosquito physiology and suggest its potential usefulness as an environmentally friendly vector control agent to reduce malaria transmission, warranting further research and field studies.