<p>The world’s largest continuous alpine permafrost layer on the Tibet Plateau (TP), is increasingly threatened by warming leading permafrost degradation that disrupts carbon, water, and nutrient cycling, and threatens ecosystem services and infrastructure stability. However, it remains unclear how permafrost sensitivity to warming varies across the TP and over time. By compiling a 20-year (2001–2020) dataset from 55 in situ monitoring sites, we find permafrost thawing rates increased from 45 ± 15 cm·10a⁻¹ (2001–2010) to 86 ± 30 cm·10a⁻¹ (2011-2020), while the temperature increasing rates at the top of permafrost rose from 0.15 ± 0.16 ^oC·10a⁻¹ to 0.38 ± 0.22 ^oC·10a⁻¹. Temperature explains 18% and 17% of the observed changes in active layer thickness and permafrost temperature, respectively, while non-temperature variables collectively account for 45%. Notably, precipitation patterns exert contrasting effects on permafrost: Increasing precipitation south of 34^oN leads to active layer thinning and permafrost cooling, while in the north it deepens the active layer and warms permafrost. Our findings underscore the crucial role of non-temperature variables in modulating permafrost responses to climate change, which is important for refining projections of carbon, nutrient, and water cycling and for safeguarding critical infrastructures in the TP and other permafrost regions.</p>