Scholarlink

<p>Elaborate kinetic control enables supramolecular self-assemblies to deviate from equilibrium, depicting profound energy landscapes with remarkable structural and functional diversity. Despite this potential, achieving an energy landscape that encompasses lamellar and inverse cubic structures remains a significant challenge, contrasting with the sophisticated structural transformations naturally orchestrated by cellular systems. Here, we present a dynamic and minimalistic Janus dendrimer self-assembly system capable of reversibly transitioning between lamellar vesicles and inverse cubic structures. By exploiting temperature-triggered non-covalent interactions, including OEG interdigitation and hydrogen bonding, conformational flexibility, and molecular packing, we reveal a rich energy landscape featuring diverse assembly pathways spanning lamellar vesicles and inverse cubosomes. Our study not only enriches the structural versatility of Janus dendrimer assemblies but also provides a foundation for advancing supramolecular systems toward applications in biomedicine, catalysis, and beyond.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Dynamic pathways in energy landscapes guiding supramolecular Janus dendrimer self-assemblies between lamellar and cubic architectures

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年8月29日

查看全文
  • Jiabin Luan,
  • Danni Wang,
  • Niels P. Kok,
  • Neshat Moslehi,
  • Ilja K. Voets,
  • Daniela A. Wilson

摘要

Elaborate kinetic control enables supramolecular self-assemblies to deviate from equilibrium, depicting profound energy landscapes with remarkable structural and functional diversity. Despite this potential, achieving an energy landscape that encompasses lamellar and inverse cubic structures remains a significant challenge, contrasting with the sophisticated structural transformations naturally orchestrated by cellular systems. Here, we present a dynamic and minimalistic Janus dendrimer self-assembly system capable of reversibly transitioning between lamellar vesicles and inverse cubic structures. By exploiting temperature-triggered non-covalent interactions, including OEG interdigitation and hydrogen bonding, conformational flexibility, and molecular packing, we reveal a rich energy landscape featuring diverse assembly pathways spanning lamellar vesicles and inverse cubosomes. Our study not only enriches the structural versatility of Janus dendrimer assemblies but also provides a foundation for advancing supramolecular systems toward applications in biomedicine, catalysis, and beyond.