Scholarlink

<p>Carbonic anhydrase (CA) mimics have received significant attention due to their promising applications in the enhanced hydration and sequestration of CO<sub>2</sub>. Herein, we report the assembly of sequence-defined peptoids into crystalline nanomaterials with controlled microenvironment of active sites as CA mimics for promoted hydration and sequestration of CO<sub>2</sub>. By incorporating specific ligands into self-assembling peptoids and coordinating these ligands with metal cations, we synthesize a variety of crystalline nanosheets and nanotubes as efficient CA mimics comparable to natural bovine CA. Molecular dynamics simulations reveal the critical roles of peptoid-Zn<sup>2+</sup> binding energy and the active site local microenvironment on the catalytic performance of these CA mimics. CO<sub>2</sub> precipitation results show that these CA mimics promote the hydration and sequestration of CO<sub>2</sub> while retaining high thermal and chemical stabilities. This study offers essential guidance for the future design of high-performance CA-mimics suitable for applications in CO<sub>2</sub> capture and sequestration.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Assembled peptoid crystalline nanomaterials as carbonic anhydrase mimics for promoted hydration and sequestration of CO2

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年8月9日

查看全文
  • Progyateg Chakma,
  • Ying Chen,
  • Bradley S. Harris,
  • Yasmene W. Elhady,
  • Renyu Zheng,
  • Mark E. Bowden,
  • Vaithiyalingam Shutthanandan,
  • Alexander B. Bard,
  • Thi Kim Hoang Trinh,
  • Xueyun Zheng,
  • Christopher J. Mundy,
  • Marcel D. Baer,
  • Chun-Long Chen

摘要

Carbonic anhydrase (CA) mimics have received significant attention due to their promising applications in the enhanced hydration and sequestration of CO2. Herein, we report the assembly of sequence-defined peptoids into crystalline nanomaterials with controlled microenvironment of active sites as CA mimics for promoted hydration and sequestration of CO2. By incorporating specific ligands into self-assembling peptoids and coordinating these ligands with metal cations, we synthesize a variety of crystalline nanosheets and nanotubes as efficient CA mimics comparable to natural bovine CA. Molecular dynamics simulations reveal the critical roles of peptoid-Zn2+ binding energy and the active site local microenvironment on the catalytic performance of these CA mimics. CO2 precipitation results show that these CA mimics promote the hydration and sequestration of CO2 while retaining high thermal and chemical stabilities. This study offers essential guidance for the future design of high-performance CA-mimics suitable for applications in CO2 capture and sequestration.