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<p>Conventional wound closure techniques, such as suturing and stapling, often cause infection, delayed healing, and tissue damage, particularly in fragile or compromised tissues. A sutureless, battery-free adhesive strip (SBF strip) is developed to integrate shape-memory-assisted mechanical approximation with impedance-matched electrical stimulation for enhanced tissue repair. The device incorporates a shape memory polymer (SMP) responsive at near-body temperature and a robust wet-adhesive interface (&gt;&#xa0;200 J m<sup>−2</sup>), enabling rapid attachment and uniform closure under mild heating (40 °C). A built-in ultrasound-driven triboelectric system achieves optimal skin-impedance matching (~50 kΩ), generating electric fields up to 0.59 kV m<sup>−1</sup> under 0.5 W cm<sup>−2</sup> to promote cellular migration and proliferation. Finite element simulations reveal that SMP-induced contraction redistributes local mechanical strain, reducing scarring. In vivo rat studies demonstrate a 61.7% reduction in scar area compared to sutures, along with improved epithelial regeneration, collagen deposition, and angiogenesis. This mechanically and electrically synergistic platform offers a scalable, battery-free wound therapy strategy, reducing dependence on external power and disposable components while enabling precision-guided healing.</p>

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Self-contracting, battery-free triboelectric wound healing strip with strong wet adhesion

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年8月5日

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  • Xiangchun Meng,
  • Xiao Xiao,
  • Sera Jeon,
  • Daniel Sanghyun Cho,
  • Kejia Zhang,
  • Yong Hyun Kwon,
  • Hyeon Mo,
  • Yoojin Park,
  • Byung-Joon Park,
  • Dabin Kim,
  • Fengyi Pang,
  • SeongMin Kim,
  • Byung-Ok Choi,
  • Keren Dai,
  • Sang-Woo Kim

摘要

Conventional wound closure techniques, such as suturing and stapling, often cause infection, delayed healing, and tissue damage, particularly in fragile or compromised tissues. A sutureless, battery-free adhesive strip (SBF strip) is developed to integrate shape-memory-assisted mechanical approximation with impedance-matched electrical stimulation for enhanced tissue repair. The device incorporates a shape memory polymer (SMP) responsive at near-body temperature and a robust wet-adhesive interface (> 200 J m−2), enabling rapid attachment and uniform closure under mild heating (40 °C). A built-in ultrasound-driven triboelectric system achieves optimal skin-impedance matching (~50 kΩ), generating electric fields up to 0.59 kV m−1 under 0.5 W cm−2 to promote cellular migration and proliferation. Finite element simulations reveal that SMP-induced contraction redistributes local mechanical strain, reducing scarring. In vivo rat studies demonstrate a 61.7% reduction in scar area compared to sutures, along with improved epithelial regeneration, collagen deposition, and angiogenesis. This mechanically and electrically synergistic platform offers a scalable, battery-free wound therapy strategy, reducing dependence on external power and disposable components while enabling precision-guided healing.