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<p>Whether and how myelin plasticity, an emerging new form of brain plasticity, is involved in autism spectrum disorder (ASD) remains unknown. Here, we identify deficits in oligodendrocyte (OL) generation and myelination in the barrel cortex (BC) of the male <i>NL3-R451C</i>-KI mouse model of ASD. These mice also show impaired texture recognition, disrupted gamma neuronal oscillations, and reduced excitability and myelination level in the BC-PV interneuron. These abnormalities can be rescued by a promyelinating strategy and are recapitulated by genetic blockade of myelination in <i>Myrf</i>-cKO mice. Furthermore, OL progenitor-specific conditional <i>NL3</i> knockout mice show similar deficits in BC-PV interneuron myelination and excitability, as well as neuronal oscillation and texture recognition, closely resembling the <i>NL3-R451C</i>-KI phenotype. Collectively, these results demonstrate that <i>NL3</i> mutations commonly cause hypomyelination and reduced excitability in BC-PV interneurons, disrupting neuronal oscillation and contributing to ASD-like sensory dysfunction. Our finding reveals a mechanism underlying ASD and highlights OLs/myelin as potential therapeutic targets for ASD.</p>

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Hypomyelination in autism-associated neuroligin-3 mutant mice impairs parvalbumin interneuron excitability, gamma oscillations, and sensory discrimination

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月10日

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  • Yongxiang He,
  • Jiong Li,
  • Wei Zheng,
  • Junhong Liu,
  • Zhaojun Dong,
  • Lu Yang,
  • Shuting Tang,
  • Yanping Zou,
  • Tianyu Gao,
  • Yuqian Yang,
  • Zhenpeng Mo,
  • Shuming Wang,
  • Yuehua He,
  • Changyong Tang,
  • Jianhong Luo,
  • Jingwei Zhao,
  • Guoqing Guo,
  • Huiliang Li,
  • Lin Xiao

摘要

Whether and how myelin plasticity, an emerging new form of brain plasticity, is involved in autism spectrum disorder (ASD) remains unknown. Here, we identify deficits in oligodendrocyte (OL) generation and myelination in the barrel cortex (BC) of the male NL3-R451C-KI mouse model of ASD. These mice also show impaired texture recognition, disrupted gamma neuronal oscillations, and reduced excitability and myelination level in the BC-PV interneuron. These abnormalities can be rescued by a promyelinating strategy and are recapitulated by genetic blockade of myelination in Myrf-cKO mice. Furthermore, OL progenitor-specific conditional NL3 knockout mice show similar deficits in BC-PV interneuron myelination and excitability, as well as neuronal oscillation and texture recognition, closely resembling the NL3-R451C-KI phenotype. Collectively, these results demonstrate that NL3 mutations commonly cause hypomyelination and reduced excitability in BC-PV interneurons, disrupting neuronal oscillation and contributing to ASD-like sensory dysfunction. Our finding reveals a mechanism underlying ASD and highlights OLs/myelin as potential therapeutic targets for ASD.