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<p>The use of piezoelectric materials to treat critical-sized bone defects typically requires additional stimulation to generate their piezoelectric properties and the implantation of scaffolds to promote bone repair. Here we present a self-reinforced piezoelectric chip and demonstrate its efficacy in the treatment of critical-sized bone defects. Specifically, the chip is comprised of the third-generation semiconductor aluminum nitride (AlN) as a piezoelectric layer, molybdenum (Mo) electrodes, and a silicon substrate with an optimized internal cavity structure. All these components are confirmed to be non-cytotoxic. This design enables the chip to provide self-sustained and long-term electrical signals in response to physiological vibrations. After being implanted into a rabbit critical-sized femoral defect model, the chip creates a localized bioelectric microenvironment, thereby promoting vascularized bone repair within 4 weeks without using any scaffolds and additional tools. Moreover, the chip can be fixed onto the clinically used orthopedic plate system, representing a universal plug-and-play strategy.</p>

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Self-reinforced piezoelectric chip for scaffold-free repair of critical-sized bone defects

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月1日

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  • Wei Li,
  • Youtian Mo,
  • Shaohua Xie,
  • Lei Fu,
  • Yan Ye,
  • Yilin Zhou,
  • Jianming Lai,
  • Wenliang Wang,
  • Yao Lu,
  • Guoqiang Li,
  • Jing Tian

摘要

The use of piezoelectric materials to treat critical-sized bone defects typically requires additional stimulation to generate their piezoelectric properties and the implantation of scaffolds to promote bone repair. Here we present a self-reinforced piezoelectric chip and demonstrate its efficacy in the treatment of critical-sized bone defects. Specifically, the chip is comprised of the third-generation semiconductor aluminum nitride (AlN) as a piezoelectric layer, molybdenum (Mo) electrodes, and a silicon substrate with an optimized internal cavity structure. All these components are confirmed to be non-cytotoxic. This design enables the chip to provide self-sustained and long-term electrical signals in response to physiological vibrations. After being implanted into a rabbit critical-sized femoral defect model, the chip creates a localized bioelectric microenvironment, thereby promoting vascularized bone repair within 4 weeks without using any scaffolds and additional tools. Moreover, the chip can be fixed onto the clinically used orthopedic plate system, representing a universal plug-and-play strategy.