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<p>The process by which the cerebral cortex generates movements to achieve different tasks remains poorly understood. Here, we leveraged the rich repertoire of well-controlled primate locomotor behaviors to study how task-specific movements are encoded across the dorsal premotor cortex (PMd), primary motor cortex (M1), and primary somatosensory cortex (S1) under naturalistic conditions. Neural population activity was confined within low-dimensional manifolds and partitioned into task-dependent and task-independent subspaces. However, the prevalence of these subspaces differed between cortical regions. PMd primarily operated within its task-dependent subspace, while S1, and to a lesser extent M1, largely evolved within their task-independent subspaces. The temporal structure of movement was encoded in the task-independent subspaces, which also dominated the PMd-to-M1 communication as the movement plans were translated into motor commands. Our results suggest that the brain utilizes different cortical regions to serialize the motor control by first performing task-specific computations in PMd to then generate task-independent commands in M1.</p>

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Regional specialization of movement encoding across the primate sensorimotor cortex

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月1日

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  • Simon Borgognon,
  • Nicolò Macellari,
  • Alexandra M. Hickey,
  • Matthew G. Perich,
  • Houman Javaheri,
  • Rafael Ornelas-Kobayashi,
  • Maude Delacombaz,
  • Christopher Hitz,
  • Florian Fallegger,
  • Stéphanie P. Lacour,
  • Erwan Bezard,
  • Eric M. Rouiller,
  • Jocelyne Bloch,
  • Tomislav Milekovic,
  • Ismael Seáñez,
  • Grégoire Courtine

摘要

The process by which the cerebral cortex generates movements to achieve different tasks remains poorly understood. Here, we leveraged the rich repertoire of well-controlled primate locomotor behaviors to study how task-specific movements are encoded across the dorsal premotor cortex (PMd), primary motor cortex (M1), and primary somatosensory cortex (S1) under naturalistic conditions. Neural population activity was confined within low-dimensional manifolds and partitioned into task-dependent and task-independent subspaces. However, the prevalence of these subspaces differed between cortical regions. PMd primarily operated within its task-dependent subspace, while S1, and to a lesser extent M1, largely evolved within their task-independent subspaces. The temporal structure of movement was encoded in the task-independent subspaces, which also dominated the PMd-to-M1 communication as the movement plans were translated into motor commands. Our results suggest that the brain utilizes different cortical regions to serialize the motor control by first performing task-specific computations in PMd to then generate task-independent commands in M1.