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<p>Impaired musical rhythm abilities and developmental speech-language related disorders are biologically and clinically intertwined. Prior work examining their relationship has primarily used small samples; here, we studied associations at population-scale by conducting the largest systematic epidemiological investigation to date (total <i>N</i> = 39,358). Based on existing theoretical frameworks, we predicted that rhythm impairment would be a significant risk factor for speech-language disorders in the general adult population. Findings were consistent across multiple independent datasets and rhythm subskills (including beat synchronization and rhythm discrimination), and aggregate meta-analyzed data showed that non-linguistic rhythm impairment is a modest but consistent risk factor for developmental speech, language, and reading disorders (OR = 1.33 [1.18 – 1.49]; <i>p</i> &lt; .0001). Further, cross-trait polygenic score analyses (total <i>N</i> = 7180) indicated shared genetic architecture between musical rhythm and reading abilities, suggesting genetic pleiotropy between musicality and language-related phenotypes.</p>

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Musical rhythm abilities and risk for developmental speech-language problems and disorders: epidemiological and polygenic associations

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月24日

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  • Srishti Nayak,
  • Enikő Ladányi,
  • Else Eising,
  • Yasmina Mekki,
  • Rachana Nitin,
  • Catherine T. Bush,
  • Daniel E. Gustavson,
  • Manuel Anglada-Tort,
  • Hope S. Lancaster,
  • Miriam A. Mosing,
  • Fredrik Ullén,
  • Cyrille L. Magne,
  • Simon E. Fisher,
  • Nori Jacoby,
  • Reyna L. Gordon

摘要

Impaired musical rhythm abilities and developmental speech-language related disorders are biologically and clinically intertwined. Prior work examining their relationship has primarily used small samples; here, we studied associations at population-scale by conducting the largest systematic epidemiological investigation to date (total N = 39,358). Based on existing theoretical frameworks, we predicted that rhythm impairment would be a significant risk factor for speech-language disorders in the general adult population. Findings were consistent across multiple independent datasets and rhythm subskills (including beat synchronization and rhythm discrimination), and aggregate meta-analyzed data showed that non-linguistic rhythm impairment is a modest but consistent risk factor for developmental speech, language, and reading disorders (OR = 1.33 [1.18 – 1.49]; p < .0001). Further, cross-trait polygenic score analyses (total N = 7180) indicated shared genetic architecture between musical rhythm and reading abilities, suggesting genetic pleiotropy between musicality and language-related phenotypes.