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<p>Chemicals produced through enzymatic reactions play a key role in the transition from a linear petrol-dependent to a circular bioeconomy. One promising approach is the conversion of single carbon (C<sub>1</sub>) molecules by biocatalysts to value-added products. Although progress has been made, current biological methods remain less cost-competitive than established chemical processes. Here, we review how single and multi-enzyme transformations, natural C<sub>1</sub>-trophic microorganisms, and organisms with transplanted synthetic C<sub>1</sub> assimilation pathways can synergize to strengthen the competitiveness of C<sub>1</sub>-based biomanufacturing. To explore the current state-of-the-art and assess the potential of C<sub>1</sub> biomanufacturing, we highlight the aforementioned bio-based methodologies and evaluate their industrial applicability through an overview of granted patents.</p>

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Industrial applicability of enzymatic and whole-cell processes for the utilization of C1 building blocks

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年8月1日

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  • Giovanni Davide Barone,
  • Ina Somvilla,
  • Hannah Pia Franziska Meier,
  • Anna Christina R. Ngo,
  • Thomas Bayer,
  • Fabio Parmeggiani,
  • Viktoria Rehbein,
  • Johann A. Hlina,
  • Pablo Domínguez de María,
  • Uwe T. Bornscheuer,
  • Dirk Tischler,
  • Sandy Schmidt

摘要

Chemicals produced through enzymatic reactions play a key role in the transition from a linear petrol-dependent to a circular bioeconomy. One promising approach is the conversion of single carbon (C1) molecules by biocatalysts to value-added products. Although progress has been made, current biological methods remain less cost-competitive than established chemical processes. Here, we review how single and multi-enzyme transformations, natural C1-trophic microorganisms, and organisms with transplanted synthetic C1 assimilation pathways can synergize to strengthen the competitiveness of C1-based biomanufacturing. To explore the current state-of-the-art and assess the potential of C1 biomanufacturing, we highlight the aforementioned bio-based methodologies and evaluate their industrial applicability through an overview of granted patents.