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<p>In daily life, we frequently encounter varying demands on working memory (WM), yet how the brain adapts to high WM load remains unclear. To address this question, we recorded intracranial EEG from hippocampus, entorhinal cortex (EC), and lateral temporal cortex (LTC) in humans performing a task with varying WM loads (load 4, 6, and 8). Using multivariate machine learning analysis, we decoded WM load using the power from each region as neural features. The results showed that the EC exhibited both higher decoding accuracy on medium-to-high load and superior cross-regional generalization. Further analysis revealed that removing EC-related information significantly reduced residual decoding accuracy in the hippocampus and LTC. Additionally, we found that WM maintenance was associated with enhanced phase synchronization between the EC and other regions. This inter-regional communication increased as WM load rose. These results suggest that under higher WM load, the brain relies more on the EC, a key connector that links and shares information with the hippocampus and LTC.</p>

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Enhanced role of the entorhinal cortex in adapting to increased working memory load

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月1日

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  • Jiayi Yang,
  • Dan Cao,
  • Chunyan Guo,
  • Lennart Stieglitz,
  • Debora Ledergerber,
  • Johannes Sarnthein,
  • Jin Li

摘要

In daily life, we frequently encounter varying demands on working memory (WM), yet how the brain adapts to high WM load remains unclear. To address this question, we recorded intracranial EEG from hippocampus, entorhinal cortex (EC), and lateral temporal cortex (LTC) in humans performing a task with varying WM loads (load 4, 6, and 8). Using multivariate machine learning analysis, we decoded WM load using the power from each region as neural features. The results showed that the EC exhibited both higher decoding accuracy on medium-to-high load and superior cross-regional generalization. Further analysis revealed that removing EC-related information significantly reduced residual decoding accuracy in the hippocampus and LTC. Additionally, we found that WM maintenance was associated with enhanced phase synchronization between the EC and other regions. This inter-regional communication increased as WM load rose. These results suggest that under higher WM load, the brain relies more on the EC, a key connector that links and shares information with the hippocampus and LTC.