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<p>Human beings may have evolved the largest asymmetries of brain organization in the animal kingdom. Hemispheric left-vs-right specialization is especially pronounced in species-unique capacities, including emotional processing such as facial judgments, language-based feats such as reading books, and creativity such as musical performances. We hence chart the largest longitudinal brain-imaging resource, and provide evidence that brain asymmetry changes continuously in a manner suggestive of neural plasticity throughout adulthood. In the UK Biobank population cohort, we demonstrate that whole-brain patterns of&#xa0;asymmetry changes show robust phenome-wide&#xa0;associations across 959 distinct variables spanning 11 categories. We also&#xa0;find that changes in brain asymmetry over years co-occur with changes among specific lifestyle markers. We uncover specific brain asymmetry changes which systematically&#xa0;co-occur with entering a new phase of life, namely&#xa0;retirement. Finally, we reveal relevance of evolving&#xa0;brain asymmetry within subjects to major disease categories across ~4500 total medical diagnoses. Our findings speak against the idea that asymmetrical neural systems are conserved throughout adulthood.</p>

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Longitudinal changes in brain asymmetry track lifestyle and disease

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月1日

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  • Karin Saltoun,
  • B. T. Thomas Yeo,
  • Lynn Paul,
  • Jorn Diedrichsen,
  • Danilo Bzdok

摘要

Human beings may have evolved the largest asymmetries of brain organization in the animal kingdom. Hemispheric left-vs-right specialization is especially pronounced in species-unique capacities, including emotional processing such as facial judgments, language-based feats such as reading books, and creativity such as musical performances. We hence chart the largest longitudinal brain-imaging resource, and provide evidence that brain asymmetry changes continuously in a manner suggestive of neural plasticity throughout adulthood. In the UK Biobank population cohort, we demonstrate that whole-brain patterns of asymmetry changes show robust phenome-wide associations across 959 distinct variables spanning 11 categories. We also find that changes in brain asymmetry over years co-occur with changes among specific lifestyle markers. We uncover specific brain asymmetry changes which systematically co-occur with entering a new phase of life, namely retirement. Finally, we reveal relevance of evolving brain asymmetry within subjects to major disease categories across ~4500 total medical diagnoses. Our findings speak against the idea that asymmetrical neural systems are conserved throughout adulthood.