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<p>The bactericidal action of some antibiotics is associated with increased ATP consumption, cellular respiration, and reactive oxygen species (ROS) formation. Here, we investigate the effects of ‘bioenergetic stress’, induced by constitutive hydrolysis of ATP and NADH, on antibiotic efficacy in <i>Escherichia coli</i>. We show that bioenergetic stress potentiates the evolution of antibiotic resistance via enhanced ROS production, mutagenic break repair, and transcription-coupled repair. In addition, bioenergetic stress potentiates antibiotic persistence via the stringent response. We propose a model in which the balance between ATP consumption versus production regulates antibiotic resistance and persistence.</p>

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Bioenergetic stress potentiates antimicrobial resistance and persistence

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月9日

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  • Barry Li,
  • Shivani Srivastava,
  • Mustafa Shaikh,
  • Gautam Mereddy,
  • Madison R. Garcia,
  • Eric N. Chiles,
  • Avi Shah,
  • Boatema Ofori-Anyinam,
  • Ting-Yu Chu,
  • Nicole J. Cheney,
  • Douglas McCloskey,
  • Xiaoyang Su,
  • Jason H. Yang

摘要

The bactericidal action of some antibiotics is associated with increased ATP consumption, cellular respiration, and reactive oxygen species (ROS) formation. Here, we investigate the effects of ‘bioenergetic stress’, induced by constitutive hydrolysis of ATP and NADH, on antibiotic efficacy in Escherichia coli. We show that bioenergetic stress potentiates the evolution of antibiotic resistance via enhanced ROS production, mutagenic break repair, and transcription-coupled repair. In addition, bioenergetic stress potentiates antibiotic persistence via the stringent response. We propose a model in which the balance between ATP consumption versus production regulates antibiotic resistance and persistence.