Scholarlink

<p>Frequent SARS-CoV-2 vaccination in vulnerable populations has raised concerns that this may contribute to T cell exhaustion, which could negatively affect the quality of immune protection. Herein, we examined the impact of repeated SARS-CoV-2 vaccination on T cell phenotypic and functional exhaustion in frail older adults in long-term care (<i>n</i> = 23), individuals on immunosuppressive drugs (<i>n</i> = 10), and healthy adults (<i>n</i> = 43), in Canada. Spike-specific CD4<sup>+</sup> and CD8<sup>+</sup> T cell levels did not decline in any cohort following repeated SARS-CoV-2 vaccination, nor did the expression of exhaustion markers on spike-specific or total T cells increase. T cell production of multiple cytokines (i.e. polyfunctionality) in response to the spike protein of SARS-CoV-2 did not decline in any cohort following repeated vaccination. None of the cohorts displayed elevated levels of terminally differentiated T cells following multiple SARS-CoV-2 vaccinations. Thus, repeated SARS-CoV-2 vaccination was not associated with increased T cell exhaustion in older frail adults, immunosuppressed individuals, or healthy adults.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

No evidence of immune exhaustion after repeated SARS-CoV-2 vaccination in vulnerable and healthy populations

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月5日

查看全文
  • Jenna M. Benoit,
  • Jessica A. Breznik,
  • Ying Wu,
  • Allison Kennedy,
  • Li-Min Liu,
  • Braeden Cowbrough,
  • Barbara Baker,
  • Megan Hagerman,
  • Catherine M. Andary,
  • Maha Mushtaha,
  • Nora Abdalla,
  • Jamie D. McNicol,
  • Gail Gauvreau,
  • Paul Y. Kim,
  • Judah A. Denburg,
  • Andrew P. Costa,
  • Darryl P. Leong,
  • Ishac Nazy,
  • MyLinh Duong,
  • Jonathan L. Bramson,
  • Maggie J. Larché,
  • Chris P. Verschoor,
  • Dawn M. E. Bowdish

摘要

Frequent SARS-CoV-2 vaccination in vulnerable populations has raised concerns that this may contribute to T cell exhaustion, which could negatively affect the quality of immune protection. Herein, we examined the impact of repeated SARS-CoV-2 vaccination on T cell phenotypic and functional exhaustion in frail older adults in long-term care (n = 23), individuals on immunosuppressive drugs (n = 10), and healthy adults (n = 43), in Canada. Spike-specific CD4+ and CD8+ T cell levels did not decline in any cohort following repeated SARS-CoV-2 vaccination, nor did the expression of exhaustion markers on spike-specific or total T cells increase. T cell production of multiple cytokines (i.e. polyfunctionality) in response to the spike protein of SARS-CoV-2 did not decline in any cohort following repeated vaccination. None of the cohorts displayed elevated levels of terminally differentiated T cells following multiple SARS-CoV-2 vaccinations. Thus, repeated SARS-CoV-2 vaccination was not associated with increased T cell exhaustion in older frail adults, immunosuppressed individuals, or healthy adults.