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<p>We evaluated temporal and genetic relationships between 176 food-liking-traits and cardio-metabolic diseases using data from the UK Biobank (N = 182,087) for observational analyses and summary-level GWAS data from FinnGen and other consortia (N = 406,565–977,323) for genetic analyses. Integrating observational and genetic results, we identified two detrimental food-liking-traits (bacon and diet-fizzy-drinks) and three protective food-liking-traits (broccoli, pizza, and lentils/beans). These food-liking-traits are associated with habitual food intake and influence cardio-metabolic proteins and biological processes. Notably, we found three genetic links: diet-fizzy-drinks with heart-failure, bacon with type-2-diabetes, and lentils/beans with type-2-diabetes, identifying 54 pleiotropic single-nucleotide-variants, impacting both phenotypes. Our data show the diet-fizzy-drinks and heart-failure link maybe not direct, as diet-fizzy-drinks liking correlates with sweet food consumption and shares variants linked to BMI, adiposity, platelet count and cardio-metabolic traits. The pleiotropic single-nucleotide-variants map to 251 tissue-specific genes, with four showing high druggability potential, highlighting personalized dietary strategies for cardio-metabolic diseases.</p>

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The health impacts and genetic architecture of food liking in cardio-metabolic diseases

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月23日

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  • Wenbo Jiang,
  • Hang Wang,
  • Yiding Geng,
  • Meijuan Guo,
  • Yingdong Zuo,
  • Sijia Han,
  • Zijie Liu,
  • Shuaijun Chen,
  • Shuzhen Fan,
  • Shangying Li,
  • Conghui Qiao,
  • Qianzhu Li,
  • Bai Li,
  • Yunpeng Zhang,
  • Wei Wei,
  • Tianshu Han

摘要

We evaluated temporal and genetic relationships between 176 food-liking-traits and cardio-metabolic diseases using data from the UK Biobank (N = 182,087) for observational analyses and summary-level GWAS data from FinnGen and other consortia (N = 406,565–977,323) for genetic analyses. Integrating observational and genetic results, we identified two detrimental food-liking-traits (bacon and diet-fizzy-drinks) and three protective food-liking-traits (broccoli, pizza, and lentils/beans). These food-liking-traits are associated with habitual food intake and influence cardio-metabolic proteins and biological processes. Notably, we found three genetic links: diet-fizzy-drinks with heart-failure, bacon with type-2-diabetes, and lentils/beans with type-2-diabetes, identifying 54 pleiotropic single-nucleotide-variants, impacting both phenotypes. Our data show the diet-fizzy-drinks and heart-failure link maybe not direct, as diet-fizzy-drinks liking correlates with sweet food consumption and shares variants linked to BMI, adiposity, platelet count and cardio-metabolic traits. The pleiotropic single-nucleotide-variants map to 251 tissue-specific genes, with four showing high druggability potential, highlighting personalized dietary strategies for cardio-metabolic diseases.