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<p>Hepatic fibrosis involves hepatocyte damage, causing blood ammonia accumulation, which exacerbates liver pathology and crosses the blood-brain barrier, inducing hepatic encephalopathy. It is meaningful to construct a therapeutic platform for targeted ammonia clearance. In this work, a biocompatible water-powered Zn micromotor is constructed as an ammonia chemotaxis platform, which can be actuated by the water splitting reaction and the self-generated Zn<sup>2+</sup> gradient. It can propel towards NH<sub>3</sub>·H<sub>2</sub>O source through the formation of complex ions [Zn(NH<sub>3</sub>)<sub>1</sub>](OH)<sup>+</sup> and [Zn(NH<sub>3</sub>)<sub>2</sub>](OH)<sup>+</sup>, representing a generalizable chemotaxis strategy via coordination reaction. In vivo, biomimetic collective behavior allows precise navigation and reduction of the intrahepatic ammonia level, reshaping the pathological microenvironment. This mechanism, operating in a green, zero-waste manner, facilitates integration of these micromotors into the domain of biological regulation. Such environment environment-adaptive platform is favorable for targeted treatment of hepatic fibrosis and hepatic encephalopathy caused by hyperammonemia, which is expected to provide inspiration for future personalized and precision medicine.</p>

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Chemotactic Zn micromotor for treatment of high blood ammonia-associated hepatic encephalopathy

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年5月15日

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  • Ye Feng,
  • Chao Gao,
  • Xiuyun Peng,
  • Bin Chen,
  • Miaomiao Ding,
  • Dailing Du,
  • Jinghui Rong,
  • Qi Lv,
  • Daniela A. Wilson,
  • Yingfeng Tu,
  • Fei Peng

摘要

Hepatic fibrosis involves hepatocyte damage, causing blood ammonia accumulation, which exacerbates liver pathology and crosses the blood-brain barrier, inducing hepatic encephalopathy. It is meaningful to construct a therapeutic platform for targeted ammonia clearance. In this work, a biocompatible water-powered Zn micromotor is constructed as an ammonia chemotaxis platform, which can be actuated by the water splitting reaction and the self-generated Zn2+ gradient. It can propel towards NH3·H2O source through the formation of complex ions [Zn(NH3)1](OH)+ and [Zn(NH3)2](OH)+, representing a generalizable chemotaxis strategy via coordination reaction. In vivo, biomimetic collective behavior allows precise navigation and reduction of the intrahepatic ammonia level, reshaping the pathological microenvironment. This mechanism, operating in a green, zero-waste manner, facilitates integration of these micromotors into the domain of biological regulation. Such environment environment-adaptive platform is favorable for targeted treatment of hepatic fibrosis and hepatic encephalopathy caused by hyperammonemia, which is expected to provide inspiration for future personalized and precision medicine.