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<p>How does the motor cortex combine simple movements (such as single finger flexion/extension) into complex movements (such as hand gestures, or playing the piano)? To address this question, motor cortical activity was recorded using intracortical multi-electrode arrays in two male people with tetraplegia as they attempted single, pairwise and higher-order finger movements. Neural activity for simultaneous movements was largely aligned with linear summation of corresponding single finger movement activities, with two violations. First, the neural activity exhibited normalization, preventing a large magnitude with an increasing number of moving fingers. Second, the neural tuning direction of weakly represented fingers changed significantly as a result of the movement of more strongly represented fingers. These deviations from linearity resulted in non-linear methods outperforming linear methods for neural decoding. Simultaneous finger movements are thus represented by the combination of individual finger movements by pseudo-linear summation.</p>

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Pseudo-linear summation explains neural geometry of multi-finger movements in human premotor cortex

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月30日

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  • Nishal P. Shah,
  • Donald Avansino,
  • Foram Kamdar,
  • Claire Nicolas,
  • Anastasia Kapitonava,
  • Carlos Vargas-Irwin,
  • Leigh R. Hochberg,
  • Chethan Pandarinath,
  • Krishna V. Shenoy,
  • Francis R. Willett,
  • Jaimie M. Henderson

摘要

How does the motor cortex combine simple movements (such as single finger flexion/extension) into complex movements (such as hand gestures, or playing the piano)? To address this question, motor cortical activity was recorded using intracortical multi-electrode arrays in two male people with tetraplegia as they attempted single, pairwise and higher-order finger movements. Neural activity for simultaneous movements was largely aligned with linear summation of corresponding single finger movement activities, with two violations. First, the neural activity exhibited normalization, preventing a large magnitude with an increasing number of moving fingers. Second, the neural tuning direction of weakly represented fingers changed significantly as a result of the movement of more strongly represented fingers. These deviations from linearity resulted in non-linear methods outperforming linear methods for neural decoding. Simultaneous finger movements are thus represented by the combination of individual finger movements by pseudo-linear summation.