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<p>While hippocampus represents spatial information through place cells for body navigation, whether motor areas employ a similar framework to guide hand reaching remains unknown. Here, we investigate tuning properties in dorsal premotor cortex (PMd) during naturalistic reach-and-grasp tasks in four monkeys. We find that 22% (132/601) of PMd neurons increase firing rates when the monkey’s hand occupies specific positions in space, forming the position fields. These cells represent the hand position highly efficiently, achieving ~80% accuracy for decoding hand trajectories with only 50 most dedicated position tuned cells ( ~ 10% of all recorded neurons). The hand position is co-represented with hand moving direction, speed, and reward location in the same population of PMd neurons, forming a mixed-selective framework to integrate positional and kinematic information. Our findings suggest field-like positional coding may be a mechanism shared across brain regions for spatial representation in goal-directed movements, including body navigation and forelimb reaching.</p>

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Hand position fields of neurons in the premotor cortex of macaques during natural reaching

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月12日

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  • Sheng-Hao Cao,
  • Xin-Yong Han,
  • Zhi-Ping Zhao,
  • Jian-Wen Gu,
  • Tian-Zi Jiang,
  • Shan Yu

摘要

While hippocampus represents spatial information through place cells for body navigation, whether motor areas employ a similar framework to guide hand reaching remains unknown. Here, we investigate tuning properties in dorsal premotor cortex (PMd) during naturalistic reach-and-grasp tasks in four monkeys. We find that 22% (132/601) of PMd neurons increase firing rates when the monkey’s hand occupies specific positions in space, forming the position fields. These cells represent the hand position highly efficiently, achieving ~80% accuracy for decoding hand trajectories with only 50 most dedicated position tuned cells ( ~ 10% of all recorded neurons). The hand position is co-represented with hand moving direction, speed, and reward location in the same population of PMd neurons, forming a mixed-selective framework to integrate positional and kinematic information. Our findings suggest field-like positional coding may be a mechanism shared across brain regions for spatial representation in goal-directed movements, including body navigation and forelimb reaching.