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<p>Proteins exhibit remarkable molecular recognition by dynamically adjusting their conformations to selectively interact with ligands at specialized binding sites. To bind hydrated ligands, proteins leverage amino acid residues with similar water affinities as the substrate, minimizing the energy required to strip water molecules from the hydrophilic substrates. In synthetic receptor design, replicating this sophisticated adaptability remains a challenge, as most artificial receptors are optimized to bind desolvated substances. Here, we show that proline-based synthetic receptors can mimic the conformational dynamics of proteins to achieve selective binding of hydrophilic and amphiphilic fluoride substances in aqueous environments. This finding highlights the critical role of receptor flexibility and strategic hydrophilicity in enhancing ligand recognition and affinity in water. Moreover, it establishes a new framework for designing versatile synthetic receptors with tunable hydrophobicity and hydrophilicity profiles.</p>

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Proline-based tripodal cages with guest-adaptive features for capturing hydrophilic and amphiphilic fluoride substances

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月4日

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  • Bo Huang,
  • Sihao Li,
  • Cong Pan,
  • Fangzhou Li,
  • Lukasz Wojtas,
  • Qiao Qiao,
  • Timothy H. Tran,
  • Laurent Calcul,
  • Wenqi Liu,
  • Chenfeng Ke,
  • Jianfeng Cai

摘要

Proteins exhibit remarkable molecular recognition by dynamically adjusting their conformations to selectively interact with ligands at specialized binding sites. To bind hydrated ligands, proteins leverage amino acid residues with similar water affinities as the substrate, minimizing the energy required to strip water molecules from the hydrophilic substrates. In synthetic receptor design, replicating this sophisticated adaptability remains a challenge, as most artificial receptors are optimized to bind desolvated substances. Here, we show that proline-based synthetic receptors can mimic the conformational dynamics of proteins to achieve selective binding of hydrophilic and amphiphilic fluoride substances in aqueous environments. This finding highlights the critical role of receptor flexibility and strategic hydrophilicity in enhancing ligand recognition and affinity in water. Moreover, it establishes a new framework for designing versatile synthetic receptors with tunable hydrophobicity and hydrophilicity profiles.