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<p>Antibiotic contamination has emerged as a global challenge, increasing antibiotic resistance and threatening human health and ecosystems. Bioremediation using microorganism offers sustainable methods to degrade such pharmaceutical contaminants. However, these microorganisms exhibit reduced activity under high-stress conditions, and are difficult to recycle and potentially leak into environment as microbial pollutions. Here we report bioprinted retrievable microalgae hydrogel networks (MHNs) by confining living microalgae in double-network hydrogels, which achieves enhanced antibiotic degradation (&gt;99.3%) and recyclable ability. Particularly, coating MHN with tannic acid (MHN@TA) generates a semipermeable membrane to prevent the leakage of microalgae (&lt;0.7% for 7 days), ensuring the containment of potential microbial biohazards. The biohybrid system protects the biological activity of microalgae, enabling antibiotic degradation up to 400 mg L<sup>−1</sup>. Free-standing MHN@TA fencing systems are also manufactured to demonstrate their practical applications. This study provides insights of microalgae-material interactions in bioremediation and offers design rationales for biohybrid systems.</p>

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Retrievable hydrogel networks with confined microalgae for efficient antibiotic degradation and enhanced stress tolerance

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年4月2日

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  • Minwen Jiang,
  • Jie Zheng,
  • Yi Tang,
  • Hai Liu,
  • Yawen Yao,
  • Jianfei Zhou,
  • Wei Lin,
  • Yuan Ma,
  • Jin Liu,
  • Jiajing Zhou

摘要

Antibiotic contamination has emerged as a global challenge, increasing antibiotic resistance and threatening human health and ecosystems. Bioremediation using microorganism offers sustainable methods to degrade such pharmaceutical contaminants. However, these microorganisms exhibit reduced activity under high-stress conditions, and are difficult to recycle and potentially leak into environment as microbial pollutions. Here we report bioprinted retrievable microalgae hydrogel networks (MHNs) by confining living microalgae in double-network hydrogels, which achieves enhanced antibiotic degradation (>99.3%) and recyclable ability. Particularly, coating MHN with tannic acid (MHN@TA) generates a semipermeable membrane to prevent the leakage of microalgae (<0.7% for 7 days), ensuring the containment of potential microbial biohazards. The biohybrid system protects the biological activity of microalgae, enabling antibiotic degradation up to 400 mg L−1. Free-standing MHN@TA fencing systems are also manufactured to demonstrate their practical applications. This study provides insights of microalgae-material interactions in bioremediation and offers design rationales for biohybrid systems.