<p>Circularly polarized luminescence (CPL) in solution offers several advantages. However, it remains challenging for organic molecules to achieve circularly polarized luminescence with high dissymmetry factor (<i>g</i>_lum) in solution. Herein, a general strategy is developed by placing chiral nematic liquid crystals (N*-LCs) behind the solution of achiral organic molecules. The selective reflection-transmission mechanism of solution-N*-LC composite system enables the generation of full-color and white circularly polarized light with |<i>g</i>_lum| even reaching 2.0. This strategy demonstrates versatility, being applicable to both aqueous and organic solutions, and effectively achieving the circularly polarized luminescence of multiple molecules with high <i>g</i>_lum values. Additionally, CPL switching and logic gate applications are successfully realized by leveraging the selective reflection-transmission mechanism of N*-LCs and the reversible acid-base responsiveness of the solution systems. This work provides a general and robust strategy for achiral organic molecules to achieve circularly polarized luminescence with high |<i>g</i>_lum| values in solutions.</p>