<p>Estimation of net CO₂ consumption by weathering in orogen is complicated as high erosion rate promotes competing processes of CO₂ consumption (silicate weathering) and releasing (sulfuric acid (H₂SO₄) dissolution of carbonate). Quantification of H₂SO₄ disturbing on weathering is missing in the Tibetan Plateau, hindering the understanding of Himalayan orogenesis impact on global carbon cycle. Here we calculate the riverine solute contributions from both carbonic and sulfuric acid mediated weathering, and their weathering fluxes with major river geochemistry dataset from the Tibetan Plateau. We find that silicate weathering is not anomalous, while carbonate weathering flux is 2.09% of the global value with 1.01% drainage area. Over 80% H₂SO₄ originated from pyrite oxidation is consumed by carbonate weathering, which counteracts ~58% of the CO₂ consumption flux by silicate weathering. The refined weathering CO₂ budget in this work provides quantitative modern evidence for pyrite weathering in orogen serving as negative feedback on atmospheric pCO₂.</p>