Scholarlink

<p>Deuterium labeling has found extensive applications across various research fields, including organic synthesis, drug design, and molecular imaging. Electrocatalytic semi-hydrogenation of alkynes offers a viable route for the synthesis of <i>Z</i>-alkenes, yet it falls short in achieving the semi-deuteration of these compounds. In this study, we report an electrochemical cobalt-catalyzed transfer deuteration reaction that proficiently accomplishes the semi-deuteration of alkynes, yielding <i>Z</i>-configuration deuterated alkene products. This reaction utilizes cost-effective cobalt salts as catalysts and employs D<sub>2</sub>O and AcOD (acetic acid-<i>d</i>) as economical and efficient deuterium sources, underscoring its practicality and feasibility. The reaction demonstrates a broad alkyne substrate scope, high reaction efficiency, good functional group compatibility, excellent <i>Z</i>-selectivity, and a remarkable degree of deuteration rate.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Electrochemical cobalt-catalyzed semi-deuteration of alkynes to access deuterated Z-alkenes

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年3月10日

查看全文
  • Wen-Jie Feng,
  • Zhe Chang,
  • Xi Lu,
  • Yao Fu

摘要

Deuterium labeling has found extensive applications across various research fields, including organic synthesis, drug design, and molecular imaging. Electrocatalytic semi-hydrogenation of alkynes offers a viable route for the synthesis of Z-alkenes, yet it falls short in achieving the semi-deuteration of these compounds. In this study, we report an electrochemical cobalt-catalyzed transfer deuteration reaction that proficiently accomplishes the semi-deuteration of alkynes, yielding Z-configuration deuterated alkene products. This reaction utilizes cost-effective cobalt salts as catalysts and employs D2O and AcOD (acetic acid-d) as economical and efficient deuterium sources, underscoring its practicality and feasibility. The reaction demonstrates a broad alkyne substrate scope, high reaction efficiency, good functional group compatibility, excellent Z-selectivity, and a remarkable degree of deuteration rate.