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<p><i>Parvimonas micra</i> (<i>P. micra</i>), an opportunistic oral pathogen associated with multiple cancers, has limited research on its role in oral squamous cell carcinoma (OSCC). This study shows that <i>P. micra</i> is enriched in OSCC tissues and positively correlated with tumor metastasis and stages. <i>P. micra</i> infection promotes OSCC metastasis by inducing hypoxia/HIF-1α, glycolysis, and autophagy. Mechanistically, <i>P. micra</i> surface protein TmpC binds to CKAP4, a receptor overexpressed in OSCC, facilitating bacterial attachment and invasion. This interaction activates HIF-1α and autophagy via CKAP4-RanBP2 and CKAP4-NBR1 pathways, driving metastasis. Targeting CKAP4 with masitinib or antibodies impairs <i>P. micra</i> attachment and abolishes <i>P. micra</i>-promoted OSCC metastasis in vitro and in vivo. Together, our findings identify <i>P. micra</i> as a pathogen that promotes OSCC metastasis and highlight that TmpC-CKAP4 interaction could be a potential therapeutic target for OSCC.</p>

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Parvimonas micra promotes oral squamous cell carcinoma metastasis through TmpC-CKAP4 axis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年3月7日

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  • Houbao Qi,
  • Haiting Gao,
  • Meihui Li,
  • Tianyong Sun,
  • Xiufeng Gu,
  • Li Wei,
  • Mengfan Zhi,
  • Zixuan Li,
  • Dachuan Fu,
  • Yiran Liu,
  • Ziyi Wei,
  • Yu Dou,
  • Qiang Feng

摘要

Parvimonas micra (P. micra), an opportunistic oral pathogen associated with multiple cancers, has limited research on its role in oral squamous cell carcinoma (OSCC). This study shows that P. micra is enriched in OSCC tissues and positively correlated with tumor metastasis and stages. P. micra infection promotes OSCC metastasis by inducing hypoxia/HIF-1α, glycolysis, and autophagy. Mechanistically, P. micra surface protein TmpC binds to CKAP4, a receptor overexpressed in OSCC, facilitating bacterial attachment and invasion. This interaction activates HIF-1α and autophagy via CKAP4-RanBP2 and CKAP4-NBR1 pathways, driving metastasis. Targeting CKAP4 with masitinib or antibodies impairs P. micra attachment and abolishes P. micra-promoted OSCC metastasis in vitro and in vivo. Together, our findings identify P. micra as a pathogen that promotes OSCC metastasis and highlight that TmpC-CKAP4 interaction could be a potential therapeutic target for OSCC.