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<p>The presence of all five of the virulence-associated genes <i>iucA, iroB, peg-344, rmpA</i>, and <i>rmpA2</i> is presently the most accurate genomic means for predicting hypervirulent <i>Klebsiella pneumoniae</i> (hvKp-p). With this longitudinal cohort study, we firstly provide novel insights into the clinical and genomic characteristics of hvKp-p in high-risk regions. Through propensity score matching, we show that hvKp-p is less likely to acquire antimicrobial resistance but develops more severe disease and result in increased mortality. HvKp-p are predominantly isolated from hospital settings and caused pneumonia in majority of the cases. ST23 and KL1 are the most common types in the hvKp-p cohort. Community-acquired and healthcare-associated infections are also identified as independent risk factors for hvKp-p. This genomic definition, albeit imperfect, offers a practical and efficient alternative to murine models, allowing for early identification and timely intervention in clinical settings.</p>

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Genomically defined hypervirulent Klebsiella pneumoniae contributed to early-onset increased mortality

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月1日

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  • Yunfei Tang,
  • Pengcheng Du,
  • Chunjing Du,
  • Ping Yang,
  • Ning Shen,
  • Thomas A. Russo,
  • Chao Liu

摘要

The presence of all five of the virulence-associated genes iucA, iroB, peg-344, rmpA, and rmpA2 is presently the most accurate genomic means for predicting hypervirulent Klebsiella pneumoniae (hvKp-p). With this longitudinal cohort study, we firstly provide novel insights into the clinical and genomic characteristics of hvKp-p in high-risk regions. Through propensity score matching, we show that hvKp-p is less likely to acquire antimicrobial resistance but develops more severe disease and result in increased mortality. HvKp-p are predominantly isolated from hospital settings and caused pneumonia in majority of the cases. ST23 and KL1 are the most common types in the hvKp-p cohort. Community-acquired and healthcare-associated infections are also identified as independent risk factors for hvKp-p. This genomic definition, albeit imperfect, offers a practical and efficient alternative to murine models, allowing for early identification and timely intervention in clinical settings.