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<p>Concurrent malaria and arbovirus infections pose significant public health challenges in tropical and subtropical regions, demanding innovative control strategies. Here, we describe a strategy that employs multifunctional engineered symbiotic bacteria to suppress concurrent transmission of malaria parasites, dengue, and Zika viruses by various vector mosquitoes. The symbiotic bacterium <i>Serratia</i> AS1, which efficiently spreads through <i>Anopheles</i> and <i>Aedes</i> populations, is engineered to simultaneously produce anti-<i>Plasmodium</i> and anti-arbovirus effector proteins controlled by a selected blood-induced promoter. Laboratory and outdoor field-cage studies show that the multifunctional engineered symbiotic strains effectively inhibit <i>Plasmodium</i> infection in <i>Anopheles</i> mosquitoes and arbovirus infection in <i>Aedes</i> mosquitoes. Our findings provide the foundation for the use of engineered symbiotic bacteria as a powerful tool to combat the concurrent transmission of malaria and arbovirus diseases.</p>

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Harnessing engineered symbionts to combat concurrent malaria and arboviruses transmission

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年3月1日

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  • Wenqian Hu,
  • Han Gao,
  • Chunlai Cui,
  • Lihua Wang,
  • Yiguan Wang,
  • Yifei Li,
  • Fang Li,
  • Yitong Zheng,
  • Tianyu Xia,
  • Sibao Wang

摘要

Concurrent malaria and arbovirus infections pose significant public health challenges in tropical and subtropical regions, demanding innovative control strategies. Here, we describe a strategy that employs multifunctional engineered symbiotic bacteria to suppress concurrent transmission of malaria parasites, dengue, and Zika viruses by various vector mosquitoes. The symbiotic bacterium Serratia AS1, which efficiently spreads through Anopheles and Aedes populations, is engineered to simultaneously produce anti-Plasmodium and anti-arbovirus effector proteins controlled by a selected blood-induced promoter. Laboratory and outdoor field-cage studies show that the multifunctional engineered symbiotic strains effectively inhibit Plasmodium infection in Anopheles mosquitoes and arbovirus infection in Aedes mosquitoes. Our findings provide the foundation for the use of engineered symbiotic bacteria as a powerful tool to combat the concurrent transmission of malaria and arbovirus diseases.