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<p>The capacity of the brain to compensate for insults during development depends on the type of cell loss, whereas the consequences of genetic mutations in the same neurons are difficult to predict. We reveal powerful compensation from outside the mouse cerebellum when the excitatory cerebellar output neurons are ablated embryonically and demonstrate that the main requirement for these neurons is for motor coordination and not basic learning and social behaviors. In contrast, loss of the homeobox transcription factors Engrailed1/2 (EN1/2) in the cerebellar excitatory lineage leads to additional deficits in adult learning and spatial working memory, despite half of the excitatory output neurons being intact. Diffusion MRI indicates increased thalamo-cortico-striatal connectivity in <i>En1/2</i> mutants, showing that the remaining excitatory neurons lacking <i>En1/2</i> exert adverse effects on extracerebellar circuits regulating motor learning and select non-motor behaviors. Thus, an absence of cerebellar output neurons is less disruptive than having cerebellar genetic mutations.</p>

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Cerebellar output neurons can impair non-motor behaviors by altering development of extracerebellar connectivity

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月21日

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  • Andrew S. Lee,
  • Tanzil M. Arefin,
  • Alina Gubanova,
  • Daniel N. Stephen,
  • Yu Liu,
  • Zhimin Lao,
  • Anjana Krishnamurthy,
  • Natalia V. De Marco García,
  • Detlef H. Heck,
  • Jiangyang Zhang,
  • Anjali M. Rajadhyaksha,
  • Alexandra L. Joyner

摘要

The capacity of the brain to compensate for insults during development depends on the type of cell loss, whereas the consequences of genetic mutations in the same neurons are difficult to predict. We reveal powerful compensation from outside the mouse cerebellum when the excitatory cerebellar output neurons are ablated embryonically and demonstrate that the main requirement for these neurons is for motor coordination and not basic learning and social behaviors. In contrast, loss of the homeobox transcription factors Engrailed1/2 (EN1/2) in the cerebellar excitatory lineage leads to additional deficits in adult learning and spatial working memory, despite half of the excitatory output neurons being intact. Diffusion MRI indicates increased thalamo-cortico-striatal connectivity in En1/2 mutants, showing that the remaining excitatory neurons lacking En1/2 exert adverse effects on extracerebellar circuits regulating motor learning and select non-motor behaviors. Thus, an absence of cerebellar output neurons is less disruptive than having cerebellar genetic mutations.