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<p>Microthrombus formation is associated with COVID-19 severity; however, the detailed mechanism remains unclear. In this study, we investigated mouse models with severe pneumonia caused by SARS-CoV-2 infection by using our in vivo two-photon imaging system. In the lungs of SARS-CoV-2-infected mice, increased expression of adhesion molecules in intravascular neutrophils prolonged adhesion time to the vessel wall, resulting in platelet aggregation and impaired lung perfusion. Re-analysis of scRNA-seq data from peripheral blood mononuclear cells from COVID-19 cases revealed increased expression levels of <i>CD44</i> and <i>SELL</i> in neutrophils in severe COVID-19 cases compared to a healthy group, consistent with our observations in the mouse model. These findings suggest that pulmonary perfusion defects caused by neutrophil adhesion to pulmonary vessels contribute to COVID-19 severity.</p>

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Neutrophil adhesion to vessel walls impairs pulmonary circulation in COVID-19 pathology

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年1月13日

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  • Hiroshi Ueki,
  • I-Hsuan Wang,
  • Maki Kiso,
  • Kenta Horie,
  • Shun Iida,
  • Sohtaro Mine,
  • Michiko Ujie,
  • Hung-Wei Hsu,
  • Chen-Hui Henry Wu,
  • Masaki Imai,
  • Tadaki Suzuki,
  • Wataru Kamitani,
  • Eiryo Kawakami,
  • Yoshihiro Kawaoka

摘要

Microthrombus formation is associated with COVID-19 severity; however, the detailed mechanism remains unclear. In this study, we investigated mouse models with severe pneumonia caused by SARS-CoV-2 infection by using our in vivo two-photon imaging system. In the lungs of SARS-CoV-2-infected mice, increased expression of adhesion molecules in intravascular neutrophils prolonged adhesion time to the vessel wall, resulting in platelet aggregation and impaired lung perfusion. Re-analysis of scRNA-seq data from peripheral blood mononuclear cells from COVID-19 cases revealed increased expression levels of CD44 and SELL in neutrophils in severe COVID-19 cases compared to a healthy group, consistent with our observations in the mouse model. These findings suggest that pulmonary perfusion defects caused by neutrophil adhesion to pulmonary vessels contribute to COVID-19 severity.