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Long-term cellular immunity of vaccines for Zaire Ebola Virus Diseases

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2024年9月3日

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  • Aurélie Wiedemann,
  • Edouard Lhomme,
  • Mélanie Huchon,
  • Emile Foucat,
  • Marion Bérerd-Camara,
  • Lydia Guillaumat,
  • Marcel Yaradouno,
  • Jacqueline Tambalou,
  • Cécile Rodrigues,
  • Alexandre Ribeiro,
  • Abdoul Habib Béavogui,
  • Christine Lacabaratz,
  • Rodolphe Thiébaut,
  • Laura Richert,
  • Yves Lévy,
  • Jamila Aboulhab,
  • Michelle Aguirre-MacKenzie,
  • Pauline Akoo,
  • Esther Akpa,
  • Robert Akpata,
  • Sara Albert,
  • Boni Maxime Ale,
  • Serry Alimamy-Bangura,
  • Pierre Andong,
  • Benetta C. Andrews,
  • Stephane Anoma,
  • Negin Atri,
  • Augustin Augier,
  • Ken Awuondo,
  • Ahidjo Ayouba,
  • Moses Badio,
  • Aminata Bagayoko,
  • Abby Balde,
  • Joséphine Balssa,
  • Lamin Molecule Bangura,
  • Kesha Barrington,
  • Eric Barte de Saint Fare,
  • Beth Baseler,
  • Ali Bauder,
  • Claire Bauduin,
  • Luke Bawo,
  • Abdoul Habib Beavogui,
  • Michael Belson,
  • Safaa Ben-Farhat,
  • Marion Bererd,
  • Nicolas Bernaud,
  • Teedoh Beyslow,
  • Neirade Biai,
  • Jeanne Billioux,
  • Shere Billouin-Frazier,
  • Blandine Binachon,
  • Julie Blie,
  • Viki Bockstal,
  • Patricia Boison,
  • Fatorma Bolay,
  • Aliou Boly,
  • Rachael Elizabeth Bonawitz,
  • Anne-Gaëlle Borg,
  • Samuel Bosompem,
  • Courtney Bozman,
  • Tyler Brady,
  • Sarah Browne,
  • Ryan Bullis,
  • Barbara Cagniard,
  • Kelly Cahill,
  • Yingyun Cai,
  • Aissata Abdoulaye Camara,
  • Aboubacar Keira Camara,
  • Alseny Modet Camara,
  • Antoine Campagne,
  • Cécilia Campion,
  • Alexandre Cantan,
  • Jennifer Cash,
  • Siew Pin Chai,
  • Francois Chambelin,
  • Michael Chea,
  • Geneviève Chêne,
  • Edouard Choi,
  • Michelle Chouinard,
  • Florence Chung,
  • Lucy Chung,
  • Séverine Ciancia,
  • Papa Ndiaga Cisse,
  • Elfrida Cline-Cole,
  • Céline Colin,
  • Beth-Ann Coller,
  • Djélikan Siaka Conde,
  • Katherine Cone,
  • Laurie Connor,
  • Nicholas Connor,
  • Joseph Boye Cooper,
  • Sandrine Couffin-Cardiergues,
  • Fatoumata Coulibaly,
  • Mariam Coulibaly,
  • Page Crew,
  • Sandrine Dabakuyo-Yonli,
  • Djeneba Dabitao,
  • Thierry Damerval,
  • Bionca Davis,
  • Gibrilla Fadlu Deen,
  • Eline Dekeyster,
  • Jean-François Delfraissy,
  • Christelle Delmas,
  • Mahamadou Diakite,
  • Alpha Diallo,
  • Fatoumata Abdoulaye Diallo,
  • Mamadou Saliou Diallo,
  • Ayouba Diarra,
  • Samba Diarra,
  • Oualy Diawara,
  • Bonnie Dighero-Kemp,
  • Samba Diop,
  • Waly Diouf,
  • Saurabh Dixit,
  • Barry Djenabou,
  • Laurie Doepel,
  • Eric D’Ortenzio,
  • Seydou Doumbia,
  • Moussa Moise Doumbia,
  • Macaya Douoguih,
  • Nelson Dozier,
  • Natasha Dubois Cauwelaert,
  • Alain DuChêne,
  • Michael Duvenhage,
  • Risa Eckes,
  • Elizabeth Elliott,
  • Luisa Enria,
  • Hélène Espérou,
  • Cécile Etienne,
  • Allison Eyler,
  • Lawrence Fakoli,
  • Mosoka Fallah,
  • Marie-Alix Fauvel,
  • Sylvain Faye,
  • John Fayiah,
  • Suzanne Fleck,
  • Vemy Fofana,
  • Karine Fouth Tchos,
  • Kokulo Franklin,
  • Daniela Fusco,
  • Auguste Gaddah,
  • Marylène Gaignet,
  • Katherine Gallagher,
  • Julie Gardner,
  • Harrison Gichini,
  • Julia Garcia Gozalbes,
  • Greg Grandits,
  • Maima Gray,
  • Brian Greenwood,
  • Nico Grobler,
  • Robin Gross,
  • Louis Grue,
  • Birgit Grund,
  • Oumar Guindo,
  • Swati Gupta,
  • Fadima Haidara,
  • Benjamin Hamzé,
  • Emma Hancox,
  • Jean-Christophe Hébert,
  • Jenny Hendriks,
  • Patricia Hensley,
  • Lisa Hensley,
  • Betsey Herpin,
  • Elisabeth Higgs,
  • Trudi Hilton,
  • Mickael Hneino,
  • Tracey-Ann Höeltermannl,
  • Horace Preston Holley,
  • Marie Hoover,
  • Natasha Howard,
  • Melissa Hughes,
  • Dicko Ilo,
  • Skip Irvine,
  • David Ishola,
  • Yvonne Jato,
  • Madison Joe,
  • Melvin Johnson,
  • Aboubacar Sidiki Kaba,
  • Jonathan Kagan,
  • Kade Kallon,
  • Michael Kamara,
  • Myriam Kante,
  • Judith Katoudi,
  • Cheick Mohamed Keita,
  • Sakoba Keita,
  • Seykou Keita,
  • Stephen B. Kennedy,
  • Babajide Keshinro,
  • Hassan Kiawu,
  • Mark Kieh,
  • Brent Killinger,
  • Moumouni Kinda,
  • Matthew Kirchoff,
  • Gregory Kocher,
  • Mamoudou Kodio,
  • Brian Kohn,
  • Lamine Koivogui,
  • Richard Kojan,
  • Cece Francis Kolié,
  • Jacques Seraphin Kolié,
  • David Kollie,
  • Stacy Kopka,
  • Bockarie Koroma,
  • Dickens Kowuor,
  • Catherine Kpayieli-Freeman,
  • Liane Kwast,
  • Christine Lacabaratz,
  • Boris Lacarra,
  • Laurie Lambert,
  • Courtney Lambeth,
  • Solange Lancrey-javal,
  • H. Clifford Lane,
  • Shadrach Langba,
  • Bolarinde Lawal,
  • Andrew Wen-Tseng Lee,
  • Shona Lee,
  • Shelley Lees,
  • Annabelle Lefevre,
  • Bailah Leigh,
  • Frederic Lemarcis,
  • Yves Lévy,
  • Claire Levy-Marchal,
  • Maarten Leyssen,
  • Edouard Lhomme,
  • Janie Liang,
  • Mameni Linga,
  • Ken Liu,
  • Brett Lowe,
  • Julia Lysander,
  • Ibrah Mahamadou,
  • Irina Maljkovic-Berry,
  • Marvington Mambiah,
  • Daniela Manno,
  • Jonathan Marchand,
  • Lindsay Marron,
  • Moses B. F. Massaquoi,
  • Laure Masson,
  • Charly Matard,
  • Steven Mazur,
  • John McCullough,
  • Katherine McFadyen,
  • Chelsea McLean,
  • Noémie Mercier,
  • Pauline Michavila,
  • Tracey Miller,
  • Niouma Pascal Millimouno,
  • Alejandra Miranda,
  • Soumaya Mohamed,
  • Tom Mooney,
  • Dally Muamba,
  • James Mulbah,
  • Rita Lukoo Ndamenyaa,
  • James Neaton,
  • Désiré Neboua,
  • Micki Nelson,
  • Kevin Newell,
  • Vinh-kim Nguyen,
  • Yusupha Njie,
  • Wissedi Njoh,
  • Anna Novotney-Barry,
  • Matthew Onorato,
  • Uma Onwuchekwa,
  • Susan Orsega,
  • Inmaculada Ortega-Perez,
  • Cynthia Osborne,
  • Tuda Otieno,
  • Davy Oulaï,
  • Sushma Patel,
  • Danielle Peart,
  • Martine Peeters,
  • James Pettitt,
  • Nathan Peiffer-Smadja,
  • Robert Phillips,
  • Jerome Pierson,
  • Peter Piot,
  • Micheal Piziali,
  • Stéphany Pong,
  • Elena Postnikova,
  • Calvin Proffitt,
  • Alexandre Quach,
  • Sinead Quigley,
  • Nadeeka Randunu,
  • Laura Richert,
  • Priscille Rivière,
  • Cynthia Robinson,
  • Céline Roy,
  • Amy Falk Russell,
  • Philip Sahr,
  • Katy Saliba,
  • Mohamed Samai,
  • Sibiry Samake,
  • Jen Sandrus,
  • Ibrahim Sanogo,
  • Yeya Sadio Sarro,
  • Serge Sawadogo,
  • Sani Sayadi,
  • Maxime Schvartz,
  • Christine Schwimmer,
  • Fatou Secka,
  • Heema Sharma,
  • Denise Shelley,
  • Bode Shobayo,
  • Sophia Siddiqui,
  • Jakub Simon,
  • Shelly Simpson,
  • Billy Muyisa Sivahera,
  • Karen Slater,
  • Mary Smolskis,
  • Elizabeth Smout,
  • Emily Snowden,
  • Anne-Aygline Soutthiphong,
  • Amadou Sow,
  • Samba O. Sow,
  • Ydrissa Sow,
  • Michael Stirratt,
  • Jeroen Stoop,
  • Guna Subramaniam,
  • Léa Surugue,
  • Nathalie Swales,
  • Sienneh Tamba,
  • Chan Tang,
  • Cheick Tangara,
  • Milagritos D. Tapia,
  • Julius Teahton,
  • Jemee Tegli,
  • Monique Termote,
  • Guillaume Thaurignac,
  • Rodolphe Thiebaut,
  • Greg Thompson,
  • John Tierney,
  • Daniel Tindanbil,
  • Abdoulaye Touré,
  • Elvis Towalid,
  • Stacey Traina,
  • Awa Traore,
  • Tijili Tyee,
  • David Vallée,
  • Renaud Vatrinet,
  • Corine Vincent,
  • Susan Vogel,
  • Cedrick Wallet,
  • Travis Warren,
  • Deborah Watson-Jones,
  • Wade Weaver,
  • Deborah Wentworth,
  • Cecelia Wesseh,
  • Hilary Whitworth,
  • Jimmy Whitworth,
  • Aurelie Wiedemann,
  • Wouter Willems,
  • Barthalomew Wilson,
  • Jayanthi Wolf,
  • Alie Wurie,
  • Delphine Yamadjako,
  • Quiawiah Yarmie,
  • Yazdan Yazdanpanah,
  • Shuiqing Yu,
  • Zara Zeggani,
  • Huanying Zhou

摘要

Recent Ebola outbreaks underscore the importance of continuous prevention and disease control efforts. Authorized vaccines include Merck’s Ervebo (rVSV-ZEBOV) and Johnson & Johnson’s two-dose combination (Ad26.ZEBOV/MVA-BN-Filo). Here, in a five-year follow-up of the PREVAC randomized trial (NCT02876328), we report the results of the immunology ancillary study of the trial. The primary endpoint is to evaluate long-term memory T-cell responses induced by three vaccine regimens: Ad26–MVA, rVSV, and rVSV–booster. Polyfunctional EBOV-specific CD4+ T-cell responses increase after Ad26 priming and are further boosted by MVA, whereas minimal responses are observed in the rVSV groups, declining after one year. In-vitro expansion for eight days show sustained EBOV-specific T-cell responses for up to 60 months post-prime vaccination with both Ad26-MVA and rVSV, with no decline. Cytokine production analysis identify shared biomarkers between the Ad26-MVA and rVSV groups. In secondary endpoint, we observed an elevation of pro-inflammatory cytokines at Day 7 in the rVSV group. Finally, we establish a correlation between EBOV-specific T-cell responses and anti-EBOV IgG responses. Our findings can guide booster vaccination recommendations and help identify populations likely to benefit from revaccination.