<p>Reservoir placement for the inflatable penile prosthesis has evolved over time with surgical safety and functional outcomes driving innovative changes. This state of the art review describes contemporary placement options for the inflatable penile prosthesis reservoir, including traditional space of Retzius placement and other alternate reservoir placements. The space of Retzius remains a familiar location for virgin placements while submuscular placement has gained popularity for its versatility and lower risk of visceral injury. The lateral retroperitoneal location can be considered for a patient with a hostile pelvis. A comparison of complications and functional outcomes highlights benefits and drawbacks of each location. This review aims to equip the prosthetic urologist with modern techniques and a surgical armamentarium that can address any reservoir placement.</p>