<p>Vasectomy, a permanent method of preventing the release of sperm, has been widely used as effective birth control, with millions of men undergoing the procedure worldwide each year. Although vasectomy is effective and relatively simple, it is still a subject that receives considerable scrutiny, especially regarding any health effects. Indeed, the relationship between vasectomy and health risks has been a controversial topic. This review includes the examination of the evidence linking vasectomy to oncologic sequelae (i.e. prostate and testicular cancer). In addition, a review of the literature linking vasectomy to sexual dysfunction, cardiovascular disease, primary progressive aphasia/frontotemporal dementia, anti-sperm antibodies, and reproductive hormone changes is also presented. Overall, vasectomy appears safe with no convincing evidence for long term health risks.</p>