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<p>Animal models of pulmonary arterial hypertension (PAH) demonstrate up-regulation of the renin angiotensin system. However, no clinical data are available to support the efficacy of angiotensin II inhibition in treatment for PAH. In this mini review, we will update the knowledge regarding regulation of the RAS system in PAH compared to primary hypertension in order to seek better treatments against PAH.</p><p></p>

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The renin-angiotensin system in models of pulmonary arterial hypertension vs primary hypertension

  • 期刊论文

  • 发表日期：

    2025年8月7日

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  • Yuki Nakayama,
  • Satoru Eguchi

摘要

Animal models of pulmonary arterial hypertension (PAH) demonstrate up-regulation of the renin angiotensin system. However, no clinical data are available to support the efficacy of angiotensin II inhibition in treatment for PAH. In this mini review, we will update the knowledge regarding regulation of the RAS system in PAH compared to primary hypertension in order to seek better treatments against PAH.