36-month durability of ultrasound renal denervation for hypertension resistant to combination therapy in RADIANCE-HTN TRIO
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发表日期:
2024年9月27日
- Michael J. Bloch,
- Ajay J. Kirtane,
- Michel Azizi,
- Felix Mahfoud,
- Jan Basile,
- Joost Daemen,
- Manish Saxena,
- Lisa Thackeray,
- Maureen McGuire,
- Lisa Claude,
- Roland E. Schmieder,
- Yale Wang,
- Nedaa Skeik,
- Richard Bae,
- Amy McMeans,
- JoAnne Goldman,
- Rose Peterson,
- James Stephen Jenkins,
- Isabelle Tutor,
- Michael Harrison,
- Angel Penning,
- Chandan Devireddy,
- Janice Lea,
- Amanda Fiebach,
- Claudia Merlin,
- Florian Rader,
- Suhail Dohad,
- Anne Tran,
- Kirin Bhatia,
- Naomi D. L. Fisher,
- Piotr Sobieszczyk,
- Ian Halliday,
- Tay Munson,
- Jason Lindsey,
- Steven Laster,
- Mathew Bunte,
- Anthony Hart,
- Dana King,
- Jamie Hall,
- Kintur Sanghvi,
- Courtney Krathen,
- Luot Lewis,
- Ashley Willitts,
- Thomas Todoran,
- Jan Basile,
- Anthony Awkar,
- Casey Palmer,
- Anna Tecklenburg,
- John Schindler,
- John Pacella,
- Matthew Muldoon,
- MaryJo Albright,
- Tracy Nicholson,
- John Flack,
- Youseff Chami,
- Abdul Moiz Hafiz,
- Emily Starkey,
- Kristal Adams,
- Nelson Bernardo,
- Judith Veis,
- Hayder Hashim,
- Suman Singh,
- Donna Whitman,
- Rick Stouffer,
- Alan Hinderliter,
- Meghan Allen,
- Tatum Scholl,
- Pete Fong,
- James Gainer,
- Sherron Crook,
- Ellen Hatchcock,
- Debbie Cohen,
- Jay Giri,
- Taisei Kobayashi,
- Robin Neubauer,
- Suveeksha Naidu,
- Ajay J. Kirtane,
- Jai Radhakrishnan,
- Candido Batres,
- Suzanne Edwards,
- Matheen Khuddus,
- Suzanne Zentko,
- Abby Touchton,
- Marti Roberson,
- Michael J. Bloch,
- Abhilash Akinapelli,
- Lisa English,
- Bridget Neumann,
- Farrel Mendelsohn,
- Hutton Brantley,
- Thomas Cawthon,
- Susan DeRamus,
- Wesley Wade,
- Robert Fishman,
- Edward Tuohy,
- Jessica LeBlanc,
- Tina McCurry,
- Amar Krishnaswamy,
- Luke Laffin,
- Christopher Bajzer,
- Marilyn Boros,
- Monica Branche,
- Josephine Abraham,
- Anu Abraham,
- Inge Stijleman,
- David Hsi,
- Scott Martin,
- Edward Portnay,
- Maryann Fiebach,
- Carolina Garavito,
- Todd Adams,
- Andrew Teklinski,
- Adam Leech,
- Patrick Drilling,
- Lynda Tulik,
- Keith Benzuly,
- James Paparello,
- Dan Fintel,
- Haydee Ramirez,
- Lauren Kats,
- Paul Huang,
- Santanu Biswas,
- Serena Risher,
- Kristina Pratt,
- Uzoma Ibebuogu,
- Karen Johnson,
- William Cushman,
- Lisa Jones,
- Leigh Jackson,
- David Landers,
- Tilak Pasala,
- Thomas Salazer,
- Peter Canino,
- Patricia Arakelian,
- Yi-Ming Yang,
- Asma Khaliq,
- Mitchell Weinberg,
- Yihenew Abetu,
- Alana Gulliver,
- J. P. Reilly,
- Joseph Garasic,
- Atul Chugh,
- Barry Bertolet,
- Brian Go,
- Raghava Gallapudi,
- Joel Cohn,
- Kevin Rogers,
- Manish Saxena,
- Anthony Mathur,
- Ajay Jain,
- Armida Balawon,
- Oliver Zongo,
- Christine Topham,
- Andrew Sharp,
- Richard Anderson,
- Elizabeth Thompson,
- Nikki Spiro,
- Elizabeth Hodges,
- Jaqueline Holder,
- Timothy Ellam,
- Alan Bagnall,
- Ralph Jackson,
- Victoria Bridgett,
- Peter Wilson,
- Neelanjan Das,
- Timothy Doulton,
- David Loader,
- Gemma Hector,
- Terry Levy,
- Clare Bent,
- Vivek Kodoth,
- Stephanie Horler,
- Sara Nix,
- Nicholas Robinson,
- Firas Al-Janabi,
- Jeremy Sayer,
- Sudha Ganesh Iyer,
- Emily Redman,
- Jonaifah Ramirez,
- Sandosh Padmanabhan,
- Faisal Sharif,
- Aishah Alhmoudi,
- Mattia Lunardi,
- Eileen Coen,
- Nicola Glynn,
- Felix Mahfoud,
- Lucas Lauder,
- Saarraaken Kulenthiran,
- Christina Koch,
- Angelika Wachter,
- Roland Schmieder,
- Axel Schmid,
- Dennis Kannenkeril,
- Ulrike Heinritz,
- Kerstin Endres-Frohlich,
- Philipp Lurz,
- Karl Rommel,
- Karl Fengler,
- Martin Petzold,
- Margit Büttner,
- Joachim Weil,
- Tolga Agdirlioglu,
- Tanja Köllner,
- Jeannine Stephan,
- Nikolaos Dagkonakis,
- Frank Hamann,
- Ute Ettl,
- Ulrike Petzsche,
- Peter Reimer,
- Martin Hausberg,
- Ralf Hinrichs,
- Isabella Di Ponio-Voit,
- Matthias Lutz,
- Philippe Gosse,
- Antoine Cremer,
- Panteleimon Papadopoulos,
- Julie Gaudissard,
- Florent Maire,
- Michel Azizi,
- Marc Sapoval,
- Marine Livrozet,
- Asma Regrag,
- Valerie Paquet,
- Pascal Delsart,
- Justin Hennicaux,
- Coralie Sommeville,
- Fabien Bertrand,
- Joost Daemen,
- Melvin Lafeber,
- Victor Zeijen,
- Amo Ruiter,
- Elisabeth Huijskens,
- Jan van Ramshorst,
- Panagiotis Xaplanteris,
- Rachid Briki,
- Quentin de Hemptinne,
- Severine Pascal,
- Katty Renard,
- Pascal Lefebvre,
- Bert Ferdinande,
- Juan F. Iglesias,
- Georg Ehert,
- Laetitia Gallego,
- Kevin Dobretz,
- Sylviane Bottone,
- Josh Costello,
- Courtney Krathan,
- Andrew McElvarr,
- John Reilly,
- Stephen Jenkins,
- Michael Cash,
- Shannon Williams,
- Maria Jarvis,
- Cheryl Laffer,
- Mark Robbins,
- Sarita Maddel,
- Maryanne Ducey,
- Suzanne Rose,
- Elizabeth DelMastro,
- Sripal Bangalore,
- Stephen Williams,
- Stanley Cabos,
- Carolina Rodriguez Alvarez,
- Eric Powers,
- Emily Hodskins,
- Vijay Paladugu,
- Bryan Wells,
- Hyun-Min Kim,
- Mohammad Rashid,
- Theophilus Owan,
- Iran Lavasani,
- Hailey Neilson,
- David Calhoun,
- Thomas McElderry,
- William Maddox,
- Suzanne Oparil,
- Sheila Kinder,
- Joseph Garasic,
- Doug Drachman,
- Randy Zusman,
- Kenneth Rosenfield,
- Danny Do,
- James O’Meara,
- Ilie Barb,
- Abby Foster,
- Alice Boyette,
- Desmond Jay,
- Robert Schwartz,
- Jo Anne Goldman,
- Jessie Goldman,
- Gary Ledley,
- Nancy Katof,
- Srinivasa Potluri,
- Scott Biedermann Jacquelyn Ward,
- Megan White,
- Laura Mauri,
- Piotr Sobieszczky,
- Alex Smith,
- Laura Aseltine,
- Eric Pauley,
- Tyrone Wade,
- David Zidar,
- Mehdi Shishehbor,
- Barry Effron,
- Marco Costa,
- Terence Semenec,
- Chanwit Roongsritong,
- Priscilla Nelson,
- Debbie Cohen,
- Jay Giri,
- Robin Neubauer,
- Thu Vo,
- Atul R. Chugh,
- Pei-Hsiu Huang,
- Powell Jose,
- Michael Jones,
- Manish Saxena,
- Melvin D. Lobo,
- Anthony Mathur,
- Ajay Jain,
- Armida Balawon,
- Olivier Zongo,
- Terry Levy,
- Clare Bent,
- David Beckett,
- Nicki Lakeman,
- Sarah Kennard,
- Andrew Sharp,
- Richard J. D’Souza,
- Sarah Statton,
- Lindsay Wilkes,
- Christine Anning,
- Jeremy Sayer,
- Sudha Ganesh Iyer,
- Nicholas Robinson,
- Annaliza Sevillano,
- Madelaine Ocampo,
- Robert Gerber,
- Mohamad Faris,
- Andrew John Marshall,
- Janet Sinclair,
- Hayley Pepper,
- Justin Davies,
- Neil Chapman,
- Paula Burak,
- Paula Carvelli,
- Sachin Jadhav,
- Jane Quinn,
- Lars Christian Rump,
- Johannes Stegbauer,
- Lars Schimmöller,
- Sebastian Potthoff,
- Claudia Schmid,
- Sylvia Roeder,
- Lukas Hafer,
- Felix Mahfoud,
- Michael Böhm,
- Sebastian Ewen,
- Saarraaken Kulenthiran,
- Angelika Wachter,
- Christina Koch,
- Karl Fengler,
- Karl-Philipp Rommel,
- Kai Trautmann,
- Roland E. Schmieder,
- Christian Ott,
- Axel Schmid,
- Michael Uder,
- Ulrike Heinritz,
- Kerstin Fröhlich-Endres,
- Sabine Genth-Zotz,
- Denise Kämpfner,
- Armin Grawe,
- Johannes Höhne,
- Bärbel Kaesberger,
- Constantin von zur Mühlen,
- Dennis Wolf,
- Markus Welzel,
- Gudrun Heinrichs,
- Barbara Trabitzsch,
- Hervé Trillaud,
- Erika Cornu,
- David Fouassier,
- Aurélien Lorthioir,
- Valérie Paquet,
- Atul Pathak,
- Benjamin Honton,
- Marianne Cottin,
- Frédéric Petit,
- Pierre Lantelme,
- Constance Berge,
- Pierre-Yves Courand,
- Fatou Langevin,
- Benjamin Longere,
- Guillaume Ledieu,
- François Pontana,
- Lida Feyz,
- Arno Ruiter,
- Elisabeth Huyskens,
- Peter Blankestijn,
- Michiel Voskuil,
- Zwaantina Rittersma,
- Helma Dolmans,
- A. A. Kroon,
- W. H. van Zwam,
- Jeannique Vranken,
- Claudia de Haan,
- Alexandre Persu,
- Jean Renkin,
- Frédéric Maes,
- Christophe Beauloye,
- Jean-Philippe Lengelé,
- Dominique Huyberechts,
- Anne Bouvier,
- Adam Witkowski,
- Andrzej Januszewicz,
- Jacek Kądziela,
- Aleksander Prejbisj,
- Dagmara Hering,
- Dariusz Ciecwierz,
- Milosz J. Jaguszewski,
- Radoslaw Owczuk,
- Ronald Victor,
- Courtney Walsh,
- Jonathan Williams,
- Sandeep Aggarwal,
- Scott Biedermann,
- Jeremy Sayer,
- Sudha Ganesh Iyer,
- Nicholas Robinson,
- Sadat Ali Edroos,
- Amit Patel,
- David Beckett,
- Justin Davies,
- Neil Chapman,
- Matthew Shun Shin,
- James Howard,
- Andrew S. P. Sharp,
- Anil Joseph,
- Richard D’Souza,
- Robert Gerber,
- Mohamad Faris,
- Andrew John Marshall,
- Cristina Elorz,
- Philipp Lurz,
- Robert Höllriegel,
- Karl Fengler,
- Karl-Philipp Rommel,
- Michael Böhm,
- Sebastian Ewen,
- Jelena Lucic,
- Roland E. Schmieder,
- Christian Ott,
- Michael Uder,
- Christian Rump,
- Johannes Stegbauer,
- Patric Kröpil
摘要
Endovascular ultrasound renal denervation (uRDN) reduced blood pressure (BP) compared to sham at 2 months in patients with resistant hypertension in the multicenter, blinded, randomized, sham-controlled RADIANCE-HTN TRIO trial. This analysis evaluates longer-term outcomes of patients randomized to uRDN. Patients with resistant hypertension to a 3-drug combination pill were randomized to uRDN (n = 69) or sham (n = 67). From 2-5 months, patients followed a standardized anti-hypertensive medication (AHM) titration protocol. At 6 months, patients were unblinded and received AHM per standard of care. In the uRDN group, 71% (49/69) completed 36-month follow-up. Screening office BP was 159/103 on 3.9 AHM. Baseline office BP on the single-pill combination was 153/99 mmHg. At 36 months, office BP changed by −14.5 ± 26.1/−9.0 ± 14.8 mmHg from screening (p < 0.001 for both) and −8.0 ± 24.5/−5.0 ± 14.6 mmHg from baseline (p = 0.007; p = 0.022) on 3.7 AHM. The efficacy of uRDN was durable to 36 months in patients with resistant hypertension with no safety concerns.