Scholarlink

Background <p>Discriminating between true papilloedema and pseudo-papilloedema is crucial, as true papilloedema can be both vision- and life-threatening.</p> Objectives <p>To test a simple method for differentiating pseudo-papilloedema from true papilloedema in patients with peripapillary hyperreflective ovoid mass-like structures (PHOMS) using optical coherence tomography (OCT).</p> Subjects <p>81 patients underwent OCT scanning of the optic nerve head (ONH) and peripapillary region following systematic guidelines. Patients were categorised into two groups: true papilloedema due to idiopathic intracranial hypertension (<i>n</i> = 34) and pseudo-papilloedema due to optic disc drusen (<i>n</i> = 40) or myopic tilted discs (<i>n</i> = 7).</p> Methods <p>PHOMS dimensions and thickness of retinal sublayers above PHOMS were measured. The retinal thickness directly above the PHOMS and perpendicular to the internal limiting membrane (the PHOMS UP thickness) was measured.</p> Results <p>While PHOMS were equal in height and width between groups, the PHOMS UP thickness was significantly larger in the true papilloedema group than in the pseudo-papilloedema group (378 µm ( ± 70 µm) vs 204 µm ( ± 47 µm), <i>P</i> &lt; 0.001).</p> Conclusions <p>In this selected cohort of patients with well-defined PHOMS, the significantly larger PHOMS UP thickness in the true papilloedema group supports the hypothesis that this condition involves both intra-axonal and interstitial fluid stasis, while pseudo-papilloedema only involves intra-axonal axoplasmic stasis. A PHOMS UP thickness greater than 300 µm may be suggestive of true papilloedema in this context. PHOMS UP thickness may serve as an additional, simple, rapid, OCT-metric to aid in differentiating pseudo-papilloedema from true papilloedema in patients with PHOMS.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Optical coherence tomography measurement of retinal layers above the peripapillary hyperreflective ovoid mass-like structure in true papilloedema and pseudo-papilloedema

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月21日

查看全文
  • Christopher Maximilian Behrens,
  • J. Alexander Fraser,
  • Sanja Cejvanovic,
  • Elisabeth Wibroe,
  • Judith Warner,
  • Steffen Hamann

摘要

Background

Discriminating between true papilloedema and pseudo-papilloedema is crucial, as true papilloedema can be both vision- and life-threatening.

Objectives

To test a simple method for differentiating pseudo-papilloedema from true papilloedema in patients with peripapillary hyperreflective ovoid mass-like structures (PHOMS) using optical coherence tomography (OCT).

Subjects

81 patients underwent OCT scanning of the optic nerve head (ONH) and peripapillary region following systematic guidelines. Patients were categorised into two groups: true papilloedema due to idiopathic intracranial hypertension (n = 34) and pseudo-papilloedema due to optic disc drusen (n = 40) or myopic tilted discs (n = 7).

Methods

PHOMS dimensions and thickness of retinal sublayers above PHOMS were measured. The retinal thickness directly above the PHOMS and perpendicular to the internal limiting membrane (the PHOMS UP thickness) was measured.

Results

While PHOMS were equal in height and width between groups, the PHOMS UP thickness was significantly larger in the true papilloedema group than in the pseudo-papilloedema group (378 µm ( ± 70 µm) vs 204 µm ( ± 47 µm), P < 0.001).

Conclusions

In this selected cohort of patients with well-defined PHOMS, the significantly larger PHOMS UP thickness in the true papilloedema group supports the hypothesis that this condition involves both intra-axonal and interstitial fluid stasis, while pseudo-papilloedema only involves intra-axonal axoplasmic stasis. A PHOMS UP thickness greater than 300 µm may be suggestive of true papilloedema in this context. PHOMS UP thickness may serve as an additional, simple, rapid, OCT-metric to aid in differentiating pseudo-papilloedema from true papilloedema in patients with PHOMS.