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Background/objectives <p>To determine whether the risk of incident, undifferentiated, anterior uveitis increases with worsening glycaemic control.</p> Subjects/methods <p>This retrospective, multicentre cohort study analysed 12,192,033 adults (&gt;= 18 years) from the TriNetX database (2010–2023). Individuals with pre-existing uveitis or systemic inflammatory diseases were excluded. The primary outcome was the incidence of undifferentiated anterior uveitis. HbA1c was modelled both categorically (non-diabetic, well-controlled diabetes [&lt;8.0%], poorly controlled diabetes [&gt;= 8.0%]) and continuously. Cox proportional hazards regression estimated adjusted hazard ratios (aHRs) with 95% confidence intervals (CIs); logistic regression modelled the continuous association.</p> Results <p>Increasing HbA1c levels were strongly associated with incident uveitis (<i>P</i> &lt; 0.001). Compared with non-diabetic controls, risk was elevated among patients with well-controlled diabetes (aHR 3.25; 95% CI 3.16–3.34) and further increased with poor control (aHR 4.07; 95% CI 3.95–4.19). For each 1% rise in HbA1c, the odds of developing uveitis increased by 10% (adjusted OR 1.10; 95% CI 1.10–1.11). Predicted probabilities rose non-linearly, reaching 1.11% at HbA1c 18%.</p> Conclusions <p>The risk of undifferentiated anterior uveitis increases with increasing HbA1c values.</p>

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Diabetes and uveitis. A large cohort evaluation of the association between glycaemic control and incident undifferentiated anterior uveitis. (The DULCE Study)

  • 期刊论文

  • 发表日期：

    2026年4月16日

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  • Courtney Oliver,
  • Nicolas Gasquet,
  • Meghan K. Berkenstock,
  • Paulina Liberman

摘要

Background/objectives

To determine whether the risk of incident, undifferentiated, anterior uveitis increases with worsening glycaemic control.

Subjects/methods

This retrospective, multicentre cohort study analysed 12,192,033 adults (>= 18 years) from the TriNetX database (2010–2023). Individuals with pre-existing uveitis or systemic inflammatory diseases were excluded. The primary outcome was the incidence of undifferentiated anterior uveitis. HbA1c was modelled both categorically (non-diabetic, well-controlled diabetes [<8.0%], poorly controlled diabetes [>= 8.0%]) and continuously. Cox proportional hazards regression estimated adjusted hazard ratios (aHRs) with 95% confidence intervals (CIs); logistic regression modelled the continuous association.

Results

Increasing HbA1c levels were strongly associated with incident uveitis (P < 0.001). Compared with non-diabetic controls, risk was elevated among patients with well-controlled diabetes (aHR 3.25; 95% CI 3.16–3.34) and further increased with poor control (aHR 4.07; 95% CI 3.95–4.19). For each 1% rise in HbA1c, the odds of developing uveitis increased by 10% (adjusted OR 1.10; 95% CI 1.10–1.11). Predicted probabilities rose non-linearly, reaching 1.11% at HbA1c 18%.

Conclusions

The risk of undifferentiated anterior uveitis increases with increasing HbA1c values.