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Background <p>To assess the association between the foveal location of choroidal vascular hyperpermeability (CVH) on indocyanine green angiography (ICGA) at the first visit and the visual acuity at the end of the follow-up in central serous chorioretinopathy (CSC).</p> Methods <p>This retrospective, observational, longitudinal study was conducted in the ophthalmology department of Lariboisière Hospital, Paris, France. Patients with CSC who underwent multimodal imaging, including ICGA, with a follow-up of more than 3 years, were included. The Early Treatment of Diabetic Retinopathy Study (ETDRS) grid was superimposed over mid-phase ICGA images at the first visit to determine CVH location. CVH were classified according to the location of the lesion within the central 3-mm ETDRS circle.</p> Results <p>Eighty-four eyes of 68 patients with a mean follow-up duration of 6.5 ± 3 years were included. Patients’ mean age was 48.3 ± 14.3 years and 59 patients (86.8%) were men. A foveal CVH was identified in 60 eyes (71.4%). The multivariate analysis showed an association between a final visual acuity worse than 0.3 logMAR (20/40 Snellen equivalent) and a lower initial visual acuity (<i>p</i> = 0.001), the presence of gravitational tracts (<i>p</i> = 0.034) and a foveal CVH at the first visit (<i>p</i> = 0.026).</p> Conclusion <p>This study suggested that the presence of a foveal CVH is associated with a decline in visual acuity over time. Our findings highlighted the importance of performing ICGA at the first visit to assess disease severity and guide the monitoring of CSC patients.</p>

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Prognostic value of foveal choroidal vascular hyperpermeability on indocyanine green angiography in central serous chorioretinopathy

  • 期刊论文

  • 发表日期：

    2026年3月20日

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  • Sofiane Khamkhoum,
  • Francine Behar Cohen,
  • Aude Couturier,
  • Alain Gaudric,
  • Elodie Bousquet

摘要

Background

To assess the association between the foveal location of choroidal vascular hyperpermeability (CVH) on indocyanine green angiography (ICGA) at the first visit and the visual acuity at the end of the follow-up in central serous chorioretinopathy (CSC).

Methods

This retrospective, observational, longitudinal study was conducted in the ophthalmology department of Lariboisière Hospital, Paris, France. Patients with CSC who underwent multimodal imaging, including ICGA, with a follow-up of more than 3 years, were included. The Early Treatment of Diabetic Retinopathy Study (ETDRS) grid was superimposed over mid-phase ICGA images at the first visit to determine CVH location. CVH were classified according to the location of the lesion within the central 3-mm ETDRS circle.

Results

Eighty-four eyes of 68 patients with a mean follow-up duration of 6.5 ± 3 years were included. Patients’ mean age was 48.3 ± 14.3 years and 59 patients (86.8%) were men. A foveal CVH was identified in 60 eyes (71.4%). The multivariate analysis showed an association between a final visual acuity worse than 0.3 logMAR (20/40 Snellen equivalent) and a lower initial visual acuity (p = 0.001), the presence of gravitational tracts (p = 0.034) and a foveal CVH at the first visit (p = 0.026).

Conclusion

This study suggested that the presence of a foveal CVH is associated with a decline in visual acuity over time. Our findings highlighted the importance of performing ICGA at the first visit to assess disease severity and guide the monitoring of CSC patients.