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Purpose <p>To assess the retinal peripheral defocus changes following femtosecond laser in situ-keratomileusis (FS-LASIK) in myopic adults and analyse influencing factors.</p> Methods <p>This study recruited 202 patients who underwent FS-LASIK with myopia at Beijing Ming Vision Eye Hospital. Participants were divided into low myopia (LM, -0.50D to -3.00D), moderate myopia (MM, -3.00D to -6.00D), and high myopia (HM, ≥-6.00D) groups according to spherical equivalent (SE). We measured axial length (AL), total retinal defocus (TRDV), and defocus values at eccentricities ranging from 0° to 53° from the fovea, and defocus values at the superior, inferior, temporal, and nasal quadrants. With a 3-month follow-up, changes in peripheral defocus (ΔRDV) were recorded and analysed.</p> Results <p>No significant differences were observed in TRDV, RDV20°-53°, and RDV-S among the three groups after surgery (all <i>P</i> &gt; 0.05). RDV at 10°-53° increased with eccentricity, while all groups showed significant reductions in hyperopic defocus at 20°-53° compared to preoperative measurements (all <i>P</i> &lt; 0.05). This reduction was more pronounced with severe myopia and greater eccentricity. Correlation analysis revealed that ΔRDV20°-30° and ΔRDV30°-40° positively correlated with SE and negatively correlated with AL and cutting thickness. ΔRDV40°-53° negatively correlated with AL. ΔRDV-T negatively correlated with SE, ΔRDV-N positively correlated with SE and negatively correlated with AL and cutting thickness (all <i>P</i> &lt; 0.05).</p> Conclusion <p>FS-LASIK does not change the asymmetric distribution of RDV after surgery. It effectively reduces hyperopic defocus within the 20°-53° range around the fovea, with greater reductions noted peripherally. Higher myopia and greater cutting thickness are associated with larger defocus reductions.</p>

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Analysis of the impact of FS-LASIK on peripheral retinal defocus and its influencing factors in myopic adults

  • 期刊论文

  • 发表日期：

    2025年12月10日

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  • Yu Li,
  • Chen Yang,
  • Bo Mei,
  • Dan Su,
  • Yi Yue,
  • Yue-Hua Zhou

摘要

Purpose

To assess the retinal peripheral defocus changes following femtosecond laser in situ-keratomileusis (FS-LASIK) in myopic adults and analyse influencing factors.

Methods

This study recruited 202 patients who underwent FS-LASIK with myopia at Beijing Ming Vision Eye Hospital. Participants were divided into low myopia (LM, -0.50D to -3.00D), moderate myopia (MM, -3.00D to -6.00D), and high myopia (HM, ≥-6.00D) groups according to spherical equivalent (SE). We measured axial length (AL), total retinal defocus (TRDV), and defocus values at eccentricities ranging from 0° to 53° from the fovea, and defocus values at the superior, inferior, temporal, and nasal quadrants. With a 3-month follow-up, changes in peripheral defocus (ΔRDV) were recorded and analysed.

Results

No significant differences were observed in TRDV, RDV20°-53°, and RDV-S among the three groups after surgery (all P > 0.05). RDV at 10°-53° increased with eccentricity, while all groups showed significant reductions in hyperopic defocus at 20°-53° compared to preoperative measurements (all P < 0.05). This reduction was more pronounced with severe myopia and greater eccentricity. Correlation analysis revealed that ΔRDV20°-30° and ΔRDV30°-40° positively correlated with SE and negatively correlated with AL and cutting thickness. ΔRDV40°-53° negatively correlated with AL. ΔRDV-T negatively correlated with SE, ΔRDV-N positively correlated with SE and negatively correlated with AL and cutting thickness (all P < 0.05).

Conclusion

FS-LASIK does not change the asymmetric distribution of RDV after surgery. It effectively reduces hyperopic defocus within the 20°-53° range around the fovea, with greater reductions noted peripherally. Higher myopia and greater cutting thickness are associated with larger defocus reductions.