Scholarlink

Background/objectives <p>Although decline in visual functions have been reported in eyes with non-advanced age-related macular degeneration (AMD), it is not known if visual functions in these eyes are influenced by structural changes on optical coherence tomography (OCT). We investigated the association between known OCT changes with photopic and scotopic visual functions.</p> Subjects/methods <p>Participants aged 55 years or over with early or intermediate AMD in at least 1 eye, and controls with healthy maculae and were included. Associations between visual functions and retinal structural changes were investigated using linear regression and survival analysis.</p> Results <p>We found that the presence of refractile drusen and nascent geographic atrophy (nGA) and were associated with poorer best-corrected visual acuity (BCVA), low luminance VA (LLVA), and increased low luminance deficit (LLD) (<i>P</i> &lt; 0.05). In survival analysis, eyes with thicker subfoveal choroidal thickness (SFCT) had a higher hazard rate of rod intercept, suggesting a decreased rod-intercept time (RIT). Eyes with nGA, drusen, refractile drusen, subretinal drusenoid deposits (SDD) have a significantly lower hazard rate of rod intercept (i.e. increased RIT, <i>P</i> &lt; 0.05). Among them, thinner SFCT, drusen, and SDD were identified as independent factors associated with an increased RIT in the final multivariable model (<i>P</i> &lt; 0.05).</p> Conclusions and relevance <p>Given the associations between visual functions with outer retinal layers thickness and presence of established precursors of progression to advanced AMD, our findings serve as a strong foundation for future investigations into the relationships between retinal phenotypes and functional changes.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Determinants of visual functions in patients with early and intermediate age-related macular degeneration: the PEONY study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月21日

查看全文
  • Fangyao Tang,
  • Shruti Chandra,
  • Manjot K. Grewal,
  • Syed Ahmer Raza,
  • Naomi Wijesingha,
  • Livia Faes,
  • Dun Jack Fu,
  • Wei-Shan Tsai,
  • Alicia Lim,
  • Sobha Sivaprasad

摘要

Background/objectives

Although decline in visual functions have been reported in eyes with non-advanced age-related macular degeneration (AMD), it is not known if visual functions in these eyes are influenced by structural changes on optical coherence tomography (OCT). We investigated the association between known OCT changes with photopic and scotopic visual functions.

Subjects/methods

Participants aged 55 years or over with early or intermediate AMD in at least 1 eye, and controls with healthy maculae and were included. Associations between visual functions and retinal structural changes were investigated using linear regression and survival analysis.

Results

We found that the presence of refractile drusen and nascent geographic atrophy (nGA) and were associated with poorer best-corrected visual acuity (BCVA), low luminance VA (LLVA), and increased low luminance deficit (LLD) (P < 0.05). In survival analysis, eyes with thicker subfoveal choroidal thickness (SFCT) had a higher hazard rate of rod intercept, suggesting a decreased rod-intercept time (RIT). Eyes with nGA, drusen, refractile drusen, subretinal drusenoid deposits (SDD) have a significantly lower hazard rate of rod intercept (i.e. increased RIT, P < 0.05). Among them, thinner SFCT, drusen, and SDD were identified as independent factors associated with an increased RIT in the final multivariable model (P < 0.05).

Conclusions and relevance

Given the associations between visual functions with outer retinal layers thickness and presence of established precursors of progression to advanced AMD, our findings serve as a strong foundation for future investigations into the relationships between retinal phenotypes and functional changes.