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Background/Objectives <p>We aimed to investigate the potential of anterior segment OCT (AS-OCT) in differentiating anterior chamber (AC) pigment and inflammatory cells.</p> Subject/Methods <p>Cross-sectional study of adults with uveitis. The exclusion criterion was corneal opacity sufficient to obscure slit lamp examination of the anterior chamber. Reference testing comprised slit lamp-based detection of pigment and Standardization of Uveitis Nomenclature (SUN) grading of intraocular inflammation. Index testing comprised CASIA2 swept-source AS-OCT acquisition, with semi-automated analysis to detect and measure hyper-reflective particles within the AC. Correlations between AS-OCT-derived counts of different-sized particles and clinical grades were explored using multilevel multivariable regression analyses.</p> Results <p>62 eyes (31 patients) were included. There was a positive correlation between AS-OCT particle counts of &gt;4 pixels (equivalent to &gt;24microns), and SUN grading (adjusted coefficient, adjCoef 24.3, 95% confidence interval 6.3 to 42.3, <i>p</i> = 0.03), strengthened in eyes clinically absent of pigment (adjCoef 20.6, 14.8 to 26.4, <i>p</i> &lt; 0.001). A positive correlation was also noted between particle counts ≤2 pixels and the presence of AC pigment clinically.</p> Conclusions <p>Swept-source (SS) AS-OCT holds potential utility in differentiating between pigment and cells within the AC, leading to improved management of individuals with or at risk of intraocular inflammation. SS AS-OCT-derived biomarkers may also provide information on uveitis aetiology, supporting the diagnosis of underlying conditions. Further work on a larger cohort, replication by other investigators and clinical teams, and clinical correlation with anterior chamber sampling will enable future clinical validation.</p>

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Differentiation of anterior chamber pigment and inflammatory cells using swept-source optical coherence tomography: a cross-sectional study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月12日

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  • Alice Bellchambers,
  • Rongling Shu,
  • Colin J. Chu,
  • Harry Petrushkin,
  • Ameenat Lola Solebo

摘要

Background/Objectives

We aimed to investigate the potential of anterior segment OCT (AS-OCT) in differentiating anterior chamber (AC) pigment and inflammatory cells.

Subject/Methods

Cross-sectional study of adults with uveitis. The exclusion criterion was corneal opacity sufficient to obscure slit lamp examination of the anterior chamber. Reference testing comprised slit lamp-based detection of pigment and Standardization of Uveitis Nomenclature (SUN) grading of intraocular inflammation. Index testing comprised CASIA2 swept-source AS-OCT acquisition, with semi-automated analysis to detect and measure hyper-reflective particles within the AC. Correlations between AS-OCT-derived counts of different-sized particles and clinical grades were explored using multilevel multivariable regression analyses.

Results

62 eyes (31 patients) were included. There was a positive correlation between AS-OCT particle counts of >4 pixels (equivalent to >24microns), and SUN grading (adjusted coefficient, adjCoef 24.3, 95% confidence interval 6.3 to 42.3, p = 0.03), strengthened in eyes clinically absent of pigment (adjCoef 20.6, 14.8 to 26.4, p < 0.001). A positive correlation was also noted between particle counts ≤2 pixels and the presence of AC pigment clinically.

Conclusions

Swept-source (SS) AS-OCT holds potential utility in differentiating between pigment and cells within the AC, leading to improved management of individuals with or at risk of intraocular inflammation. SS AS-OCT-derived biomarkers may also provide information on uveitis aetiology, supporting the diagnosis of underlying conditions. Further work on a larger cohort, replication by other investigators and clinical teams, and clinical correlation with anterior chamber sampling will enable future clinical validation.